Detailed information of TA system TA135808

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4586644..4587347
• Replicon: chromosome
• Accession: NZ_CP042520
• Organism: Klebsiella pneumoniae strain C2

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: FR744_RS22625
• Protein ID: WP_042093716.1
• Coordinates: 4586644..4586985 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: FR744_RS22630
• Protein ID: WP_042093718.1
• Coordinates: 4587006..4587347 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR744_RS22605	4582128..4583615	+	1488	WP_021441098.1	hypothetical protein	-
FR744_RS22620	4585378..4586385	-	1008	WP_097320785.1	restriction endonuclease	-
FR744_RS22625	4586644..4586985	-	342	WP_042093716.1	TA system toxin CbtA family protein	Toxin
FR744_RS22630	4587006..4587347	-	342	WP_042093718.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FR744_RS22635	4587334..4587900	-	567	WP_151641762.1	DNA repair protein RadC	-
FR744_RS22640	4587912..4588352	-	441	WP_039567646.1	antirestriction protein	-
FR744_RS22645	4588383..4589204	-	822	WP_039567648.1	DUF945 domain-containing protein	-
FR744_RS22650	4589325..4589798	-	474	WP_039567650.1	hypothetical protein	-
FR744_RS22660	4591206..4591658	-	453	WP_080311526.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4573103..4621963	48860
	-	inside	IScluster/Tn	-	-	4583898..4591079	7181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12741.73 Da
• Isoelectric Point: 8.0583

>T135808 WP_042093716.1 NZ_CP042520:c4586985-4586644 [Klebsiella pneumoniae]
MKTLPATNPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVILEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRHRISAAR

Nucleotide

• Length: 342 bp

>T135808 NZ_CP055167:2699750-2699857 [Shigella flexneri]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12883.62 Da
• Isoelectric Point: 6.6222

>AT135808 WP_042093718.1 NZ_CP042520:c4587347-4587006 [Klebsiella pneumoniae]
MKYTELENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTDEINPRH
ARCVTLYHNGFTCEADTLGSCGYVYVAVYPTHR

Nucleotide

• Length: 342 bp

>AT135808 NZ_CP042520:c4587347-4587006 [Klebsiella pneumoniae]
ATGAAATATACTGAATTAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGATGAAATAAATCCTCGCCAT
GCCCGCTGCGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACGTCGC
CGTTTACCCCACTCATCGTTAA