Detailed information of TA system TA135796

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 846096..846753
• Replicon: chromosome
• Accession: NZ_CP042520
• Organism: Klebsiella pneumoniae strain C2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FR744_RS04360
• Protein ID: WP_130949114.1
• Coordinates: 846343..846753 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: FR744_RS04355
• Protein ID: WP_002916312.1
• Coordinates: 846096..846362 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR744_RS04330	841304..842737	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
FR744_RS04335	842856..843584	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
FR744_RS04340	843634..843945	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
FR744_RS04345	844109..844768	+	660	WP_002916317.1	hemolysin III family protein	-
FR744_RS04350	844867..845850	-	984	WP_023286864.1	tRNA-modifying protein YgfZ	-
FR744_RS04355	846096..846362	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
FR744_RS04360	846343..846753	+	411	WP_130949114.1	protein YgfX	Toxin
FR744_RS04365	846760..847281	-	522	WP_004144730.1	flavodoxin FldB	-
FR744_RS04370	847382..848278	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
FR744_RS04375	848301..849014	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FR744_RS04380	849020..850753	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16083.87 Da
• Isoelectric Point: 11.4778

>T135796 WP_130949114.1 NZ_CP042520:846343-846753 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEIFGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T135796 NZ_CP042520:846343-846753 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCTTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT135796 WP_002916312.1 NZ_CP042520:846096-846362 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT135796 NZ_CP042520:846096-846362 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41