Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1650784..1651423 Replicon chromosome
Accession NZ_CP042517
Organism Citrobacter freundii strain E33

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FR815_RS08130 Protein ID WP_071684398.1
Coordinates 1650784..1650960 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FR815_RS08135 Protein ID WP_123924900.1
Coordinates 1651007..1651423 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR815_RS08110 1647562..1647792 - 231 WP_003020233.1 DUF2554 family protein -
FR815_RS08115 1647982..1648107 - 126 WP_003020230.1 DUF2474 domain-containing protein -
FR815_RS08120 1648107..1649117 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
FR815_RS08125 1649117..1650520 - 1404 WP_003843730.1 cytochrome ubiquinol oxidase subunit I -
FR815_RS08130 1650784..1650960 + 177 WP_071684398.1 type II toxin-antitoxin system HicA family toxin Toxin
FR815_RS08135 1651007..1651423 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FR815_RS08140 1651516..1652925 + 1410 WP_003836140.1 PLP-dependent aminotransferase family protein -
FR815_RS08145 1653253..1654398 + 1146 WP_003020212.1 ABC transporter substrate-binding protein -
FR815_RS08150 1654415..1655431 + 1017 WP_119174242.1 ABC transporter ATP-binding protein -
FR815_RS08155 1655432..1656376 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.86 Da        Isoelectric Point: 11.6208

>T135781 WP_071684398.1 NZ_CP042517:1650784-1650960 [Citrobacter freundii]
VKQSKFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

>T135781 NZ_CP042517:1650784-1650960 [Citrobacter freundii]
GTGAAGCAAAGTAAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT135781 WP_123924900.1 NZ_CP042517:1651007-1651423 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp

>AT135781 NZ_CP042517:1651007-1651423 [Citrobacter freundii]
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCGGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References