Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4466303..4466972 Replicon chromosome
Accession NZ_CP042512
Organism Serratia marcescens strain E28

Toxin (Protein)


Gene name cptA Uniprot ID A0A5P6GZ53
Locus tag FR888_RS21805 Protein ID WP_047729923.1
Coordinates 4466303..4466725 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag FR888_RS21810 Protein ID WP_019455657.1
Coordinates 4466706..4466972 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR888_RS21785 4462193..4462711 + 519 WP_038871234.1 flavodoxin FldB -
FR888_RS21790 4462748..4464112 - 1365 WP_055312418.1 cell envelope integrity protein CreD -
FR888_RS21795 4464193..4465611 - 1419 WP_047729925.1 two-component system sensor histidine kinase CreC -
FR888_RS21800 4465608..4466303 - 696 WP_055316660.1 two-component system response regulator CreB -
FR888_RS21805 4466303..4466725 - 423 WP_047729923.1 protein YgfX Toxin
FR888_RS21810 4466706..4466972 - 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
FR888_RS21815 4467293..4468285 + 993 WP_047729922.1 tRNA-modifying protein YgfZ -
FR888_RS21820 4468324..4468821 - 498 WP_038871226.1 DUF2165 domain-containing protein -
FR888_RS21825 4468972..4469646 - 675 WP_038871224.1 hemolysin III family protein -
FR888_RS21830 4469830..4470438 + 609 WP_025304127.1 HD domain-containing protein -
FR888_RS21835 4470471..4471397 - 927 WP_047729921.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16500.57 Da        Isoelectric Point: 10.8114

>T135767 WP_047729923.1 NZ_CP042512:c4466725-4466303 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPVGDGEEA

Download         Length: 423 bp

>T135767 NZ_CP042512:c4466725-4466303 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
TGGGTGACGGCGAGGAGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT135767 WP_019455657.1 NZ_CP042512:c4466972-4466706 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT135767 NZ_CP042512:c4466972-4466706 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GZ53

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References