Detailed information of TA system TA135765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4068200..4068856
• Replicon: chromosome
• Accession: NZ_CP042512
• Organism: Serratia marcescens strain E28

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: FR888_RS19920
• Protein ID: WP_047730091.1
• Coordinates: 4068200..4068589 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: FR888_RS19925
• Protein ID: WP_004941563.1
• Coordinates: 4068593..4068856 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR888_RS19905	4064669..4066099	+	1431	WP_060434507.1	MFS transporter	-
FR888_RS19910	4066096..4067469	+	1374	WP_060434510.1	two-component system sensor histidine kinase BaeS	-
FR888_RS19915	4067479..4068195	+	717	WP_047730092.1	two-component system response regulator BaeR	-
FR888_RS19920	4068200..4068589	-	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
FR888_RS19925	4068593..4068856	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FR888_RS19930	4069195..4069533	+	339	WP_038873760.1	YegP family protein	-
FR888_RS19935	4069835..4071187	+	1353	WP_038873761.1	tRNA 5-hydroxyuridine modification protein YegQ	-
FR888_RS19940	4071655..4072560	+	906	WP_038873764.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T135765 WP_047730091.1 NZ_CP042512:c4068589-4068200 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T135765 NZ_CP042512:c4068589-4068200 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAAGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAGAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT135765 WP_004941563.1 NZ_CP042512:c4068856-4068593 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT135765 NZ_CP042512:c4068856-4068593 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A5C7DE55