Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3987566..3988128 Replicon chromosome
Accession NZ_CP042512
Organism Serratia marcescens strain E28

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FR888_RS19550 Protein ID WP_047730131.1
Coordinates 3987566..3987922 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag FR888_RS19555 Protein ID WP_004936539.1
Coordinates 3987919..3988128 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR888_RS19530 3983300..3984097 - 798 WP_060434343.1 energy transducer TonB -
FR888_RS19535 3984200..3985039 - 840 WP_060434341.1 ChaN family lipoprotein -
FR888_RS19540 3985217..3986626 + 1410 WP_060434339.1 S-methylmethionine permease -
FR888_RS19545 3986616..3987554 + 939 WP_060434336.1 homocysteine S-methyltransferase -
FR888_RS19550 3987566..3987922 - 357 WP_047730131.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FR888_RS19555 3987919..3988128 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FR888_RS19560 3988237..3990516 - 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
FR888_RS28615 3990732..3990905 - 174 WP_038881246.1 hypothetical protein -
FR888_RS19565 3990886..3991266 - 381 WP_047730130.1 DUF2570 family protein -
FR888_RS19570 3991263..3991664 - 402 WP_038881240.1 M15 family metallopeptidase -
FR888_RS19575 3991654..3991980 - 327 WP_055313439.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13161.95 Da        Isoelectric Point: 4.9139

>T135764 WP_047730131.1 NZ_CP042512:c3987922-3987566 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Download         Length: 357 bp

>T135764 NZ_CP042512:c3987922-3987566 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT135764 WP_004936539.1 NZ_CP042512:c3988128-3987919 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT135764 NZ_CP042512:c3988128-3987919 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References