Detailed information of TA system TA135763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3629412..3630024
• Replicon: chromosome
• Accession: NZ_CP042512
• Organism: Serratia marcescens strain E28

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: FR888_RS17635
• Protein ID: WP_012906750.1
• Coordinates: 3629412..3629591 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FR888_RS17640
• Protein ID: WP_151523071.1
• Coordinates: 3629614..3630024 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR888_RS17595	3624631..3625164	+	534	WP_013813841.1	hypothetical protein	-
FR888_RS17600	3625164..3625346	+	183	WP_151523098.1	DUF1482 family protein	-
FR888_RS17605	3625343..3626107	+	765	WP_151523099.1	hypothetical protein	-
FR888_RS17610	3626253..3626771	+	519	WP_151523100.1	hypothetical protein	-
FR888_RS17615	3626771..3627265	+	495	WP_151523101.1	hypothetical protein	-
FR888_RS17620	3627313..3627531	+	219	WP_013813848.1	hypothetical protein	-
FR888_RS17625	3627531..3628709	+	1179	WP_151523102.1	phage integrase Arm DNA-binding domain-containing protein	-
FR888_RS17630	3628741..3628950	-	210	WP_151523103.1	hypothetical protein	-
FR888_RS17635	3629412..3629591	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
FR888_RS17640	3629614..3630024	+	411	WP_151523071.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FR888_RS17645	3630070..3630576	+	507	WP_151523072.1	acetyltransferase	-
FR888_RS17650	3630578..3631033	-	456	WP_192802289.1	tail fiber assembly protein	-
FR888_RS17660	3632146..3632373	-	228	Protein_3439	phage tail protein	-
FR888_RS17665	3632360..3632947	-	588	WP_151523073.1	DUF2313 domain-containing protein	-
FR888_RS17670	3632951..3634024	-	1074	WP_151523074.1	baseplate J/gp47 family protein	-
FR888_RS17675	3634017..3634430	-	414	WP_151523141.1	phage GP46 family protein	-
FR888_RS17680	3634430..3634966	-	537	WP_048796478.1	phage baseplate assembly protein V	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T135763 WP_012906750.1 NZ_CP042512:3629412-3629591 [Serratia marcescens]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T135763 NZ_CP042512:3629412-3629591 [Serratia marcescens]
ATGGATAGCAGGAATGCAATAGCAATGATTGAAGCCGATGGGTGGTATCTGGTGAGAGTGAAAGGCAGTCATCATCAGTT
CAAGCACCCAACGAAGAAAGGGCTGGTAACGGTAAAACACCCACAGAAAGACATACCGCTGCCAACACTGAAAAGTATCA
AGAAACAGGCGGGGCTCTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14889.77 Da
• Isoelectric Point: 4.2518

>AT135763 WP_151523071.1 NZ_CP042512:3629614-3630024 [Serratia marcescens]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIEAHIELLVEDGEAVPVGTNVETWLSDPDYAGVVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADRVISWENR

Nucleotide

• Length: 411 bp

>AT135763 NZ_CP042512:3629614-3630024 [Serratia marcescens]
ATGCTGTATCCAGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTTTCTGG
CGGCGACAATTATCAGGATGCGATCGAGAGCGCGCGCGAAGCCATCGAGGCACATATTGAATTGTTGGTTGAAGATGGCG
AAGCAGTACCGGTGGGAACCAACGTTGAAACCTGGTTATCTGATCCAGATTACGCCGGCGTCGTCTGGGCGCTCGTAGAT
GTAGATATCACCAGGCTTATGGGAAAAGCGGAGAAAATCAACGTAACACTTCCTTCCCTGCTGATCCGTCGCATCGACCA
GTTTGTCGCCGCGCATCCTGAGTACGGAAGCCGTTCTGGCTTCCTCTCACGGGTTGCAGCTGATAGAGTGATAAGCTGGG
AAAATCGTTAA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4