Detailed information of TA system TA135761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3550760..3551372
• Replicon: chromosome
• Accession: NZ_CP042512
• Organism: Serratia marcescens strain E28

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: FR888_RS17035
• Protein ID: WP_012906750.1
• Coordinates: 3550760..3550939 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FR888_RS17040
• Protein ID: WP_151523071.1
• Coordinates: 3550962..3551372 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR888_RS17010	3546765..3547049	+	285	WP_019453645.1	50S ribosomal protein L25	-
FR888_RS17015	3547134..3548141	-	1008	WP_047730233.1	nucleoid-associated protein YejK	-
FR888_RS17020	3548353..3548580	+	228	WP_004935782.1	YejL family protein	-
FR888_RS17025	3548590..3550371	+	1782	WP_060433679.1	LPS biosynthesis-modulating metalloenzyme YejM	-
FR888_RS17035	3550760..3550939	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
FR888_RS17040	3550962..3551372	+	411	WP_151523071.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FR888_RS17045	3551418..3551924	+	507	WP_151523072.1	acetyltransferase	-
FR888_RS17050	3551926..3552381	-	456	WP_192802289.1	tail fiber assembly protein	-
FR888_RS17060	3553494..3553721	-	228	Protein_3325	phage tail protein	-
FR888_RS17065	3553708..3554295	-	588	WP_151523073.1	DUF2313 domain-containing protein	-
FR888_RS17070	3554299..3555372	-	1074	WP_151523074.1	baseplate J/gp47 family protein	-
FR888_RS17075	3555365..3555778	-	414	WP_151523141.1	phage GP46 family protein	-
FR888_RS17080	3555778..3556314	-	537	WP_048796478.1	phage baseplate assembly protein V	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T135761 WP_012906750.1 NZ_CP042512:3550760-3550939 [Serratia marcescens]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T135761 NZ_CP042512:3550760-3550939 [Serratia marcescens]
ATGGATAGCAGGAATGCAATAGCAATGATTGAAGCCGATGGGTGGTATCTGGTGAGAGTGAAAGGCAGTCATCATCAGTT
CAAGCACCCAACGAAGAAAGGGCTGGTAACGGTAAAACACCCACAGAAAGACATACCGCTGCCAACACTGAAAAGTATCA
AGAAACAGGCGGGGCTCTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14889.77 Da
• Isoelectric Point: 4.2518

>AT135761 WP_151523071.1 NZ_CP042512:3550962-3551372 [Serratia marcescens]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIEAHIELLVEDGEAVPVGTNVETWLSDPDYAGVVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADRVISWENR

Nucleotide

• Length: 411 bp

>AT135761 NZ_CP042512:3550962-3551372 [Serratia marcescens]
ATGCTGTATCCAGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTTTCTGG
CGGCGACAATTATCAGGATGCGATCGAGAGCGCGCGCGAAGCCATCGAGGCACATATTGAATTGTTGGTTGAAGATGGCG
AAGCAGTACCGGTGGGAACCAACGTTGAAACCTGGTTATCTGATCCAGATTACGCCGGCGTCGTCTGGGCGCTCGTAGAT
GTAGATATCACCAGGCTTATGGGAAAAGCGGAGAAAATCAACGTAACACTTCCTTCCCTGCTGATCCGTCGCATCGACCA
GTTTGTCGCCGCGCATCCTGAGTACGGAAGCCGTTCTGGCTTCCTCTCACGGGTTGCAGCTGATAGAGTGATAAGCTGGG
AAAATCGTTAA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4