Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3183414..3184045 Replicon chromosome
Accession NZ_CP042512
Organism Serratia marcescens strain E28

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P6GW52
Locus tag FR888_RS15395 Protein ID WP_047730458.1
Coordinates 3183414..3183812 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3SVC2
Locus tag FR888_RS15400 Protein ID WP_047730457.1
Coordinates 3183812..3184045 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR888_RS15375 3178517..3179332 - 816 WP_055316342.1 5'-nucleotidase, lipoprotein e(P4) family -
FR888_RS15380 3179661..3180065 - 405 WP_047730460.1 flagellar protein FlhE -
FR888_RS15385 3180065..3182143 - 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
FR888_RS15390 3182136..3183287 - 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
FR888_RS15395 3183414..3183812 - 399 WP_047730458.1 type II toxin-antitoxin system VapC family toxin Toxin
FR888_RS15400 3183812..3184045 - 234 WP_047730457.1 antitoxin Antitoxin
FR888_RS15405 3184171..3184815 - 645 WP_004934858.1 protein phosphatase CheZ -
FR888_RS15410 3184826..3185215 - 390 WP_004934862.1 chemotaxis response regulator CheY -
FR888_RS15415 3185318..3186367 - 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
FR888_RS15420 3186367..3187239 - 873 WP_060433358.1 protein-glutamate O-methyltransferase CheR -
FR888_RS15425 3187277..3188893 - 1617 WP_047730456.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14960.14 Da        Isoelectric Point: 7.4664

>T135760 WP_047730458.1 NZ_CP042512:c3183812-3183414 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEVFNRYAGKMVISSITYGELVHGVENSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAVLERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T135760 NZ_CP042512:c3183812-3183414 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGTATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8841.85 Da        Isoelectric Point: 4.7815

>AT135760 WP_047730457.1 NZ_CP042512:c3184045-3183812 [Serratia marcescens]
MALGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT135760 NZ_CP042512:c3184045-3183812 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GW52

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SVC2

References