Detailed information of TA system TA135751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1720075..1720670
• Replicon: chromosome
• Accession: NZ_CP042512
• Organism: Serratia marcescens strain E28

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: FR888_RS08200
• Protein ID: WP_071605322.1
• Coordinates: 1720075..1720329 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FR888_RS08205
• Protein ID: WP_033633573.1
• Coordinates: 1720329..1720670 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR888_RS08165	1715255..1716028	+	774	WP_038881165.1	ankyrin repeat domain-containing protein	-
FR888_RS08170	1716118..1716861	+	744	WP_038881168.1	ankyrin repeat domain-containing protein	-
FR888_RS08175	1717029..1718007	+	979	Protein_1575	replication endonuclease	-
FR888_RS08180	1718046..1718270	+	225	WP_038881170.1	hypothetical protein	-
FR888_RS08185	1718303..1718563	-	261	WP_139145145.1	hypothetical protein	-
FR888_RS08190	1718720..1719421	+	702	WP_038881175.1	hypothetical protein	-
FR888_RS08200	1720075..1720329	+	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
FR888_RS08205	1720329..1720670	+	342	WP_033633573.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FR888_RS08210	1720790..1721995	+	1206	WP_151522949.1	ISL3 family transposase	-
FR888_RS08215	1722033..1723055	-	1023	WP_038880680.1	phage portal protein	-
FR888_RS08220	1723055..1724164	-	1110	Protein_1583	oxidoreductase	-
FR888_RS08225	1724115..1724330	+	216	WP_071605333.1	ogr/Delta-like zinc finger family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T135751 WP_071605322.1 NZ_CP042512:1720075-1720329 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T135751 NZ_CP042512:1720075-1720329 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCTATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12399.90 Da
• Isoelectric Point: 4.5789

>AT135751 WP_033633573.1 NZ_CP042512:1720329-1720670 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT135751 NZ_CP042512:1720329-1720670 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAACGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCTCAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1