Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1071502..1072124 Replicon chromosome
Accession NZ_CP042512
Organism Serratia marcescens strain E28

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag FR888_RS05065 Protein ID WP_004940313.1
Coordinates 1071502..1071705 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag FR888_RS05070 Protein ID WP_004940312.1
Coordinates 1071756..1072124 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR888_RS05040 1067310..1067756 + 447 WP_047728676.1 type II secretion system protein M -
FR888_RS05045 1067793..1068608 + 816 WP_047728674.1 A24 family peptidase -
FR888_RS05050 1068605..1068967 - 363 WP_151522942.1 type II secretion system pilot lipoprotein GspS -
FR888_RS05055 1069220..1070647 + 1428 WP_060435143.1 N-acetylglucosamine-binding protein GbpA -
FR888_RS05060 1070700..1071218 + 519 WP_047728667.1 cytochrome b/b6 domain-containing protein -
FR888_RS05065 1071502..1071705 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
FR888_RS05070 1071756..1072124 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
FR888_RS05075 1072283..1072636 - 354 WP_038874974.1 hypothetical protein -
FR888_RS05080 1073046..1073759 + 714 WP_060435145.1 ABC transporter ATP-binding protein -
FR888_RS05085 1073756..1074613 + 858 WP_038874980.1 metal ABC transporter permease -
FR888_RS05090 1074639..1075517 + 879 WP_038874983.1 zinc ABC transporter substrate-binding protein -
FR888_RS05095 1075624..1075764 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
FR888_RS05100 1075777..1076031 - 255 WP_038874985.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T135750 WP_004940313.1 NZ_CP042512:c1071705-1071502 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T135750 NZ_CP042512:c1071705-1071502 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT135750 WP_004940312.1 NZ_CP042512:c1072124-1071756 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT135750 NZ_CP042512:c1072124-1071756 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References