Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 472144..472715 Replicon chromosome
Accession NZ_CP042512
Organism Serratia marcescens strain E28

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3SNA4
Locus tag FR888_RS02230 Protein ID WP_038879053.1
Coordinates 472440..472715 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag FR888_RS02225 Protein ID WP_013811307.1
Coordinates 472144..472431 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR888_RS02200 467913..468998 - 1086 WP_033636846.1 carbon-phosphorus lyase complex subunit PhnI -
FR888_RS02205 468998..469579 - 582 WP_060434790.1 phosphonate C-P lyase system protein PhnH -
FR888_RS02210 469583..470026 - 444 WP_019453314.1 phosphonate C-P lyase system protein PhnG -
FR888_RS02215 470027..470755 - 729 WP_015376439.1 phosphonate metabolism transcriptional regulator PhnF -
FR888_RS02220 470983..472038 + 1056 WP_060434788.1 permease -
FR888_RS02225 472144..472431 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FR888_RS02230 472440..472715 + 276 WP_038879053.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FR888_RS02235 472721..473185 - 465 WP_033636852.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FR888_RS02240 473354..475492 - 2139 WP_047729217.1 anaerobic ribonucleoside-triphosphate reductase -
FR888_RS02245 475737..476651 - 915 WP_048232521.1 LysR family transcriptional regulator -
FR888_RS02250 476758..477282 + 525 WP_047729213.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.52 Da        Isoelectric Point: 9.5103

>T135749 WP_038879053.1 NZ_CP042512:472440-472715 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T135749 NZ_CP042512:472440-472715 [Serratia marcescens]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGTCTGCTGGATCATCCTGAGTTAGGTAAGCCTTGGTATG
GGAAGGCACGTAAGTTGCTAATTAACAAGGCCTCTCTGTTGCTGGTGTATATCATCGTCGATGATGTTATTAAGGTTTTC
TCGATTGCCCACCAGCGTGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT135749 WP_013811307.1 NZ_CP042512:472144-472431 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT135749 NZ_CP042512:472144-472431 [Serratia marcescens]
ATGGAAAGTCGCATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCGGAAGCTAAAGGAACGAC
ATTGAGTGAAGCCTGCCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCCGCGGAGGAGCACGAAAATTGGTTGA
AAGATAAGGTGGATGCAGCTTTTTCCCGTCTGCATGAGGGTAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATTAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3SNA4

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References