Detailed information of TA system TA135748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 188423..188895
• Replicon: chromosome
• Accession: NZ_CP042512
• Organism: Serratia marcescens strain E28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P6GNV0
• Locus tag: FR888_RS00900
• Protein ID: WP_048232401.1
• Coordinates: 188620..188895 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FR888_RS00895
• Protein ID: WP_060433781.1
• Coordinates: 188423..188620 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR888_RS00865	183601..184869	+	1269	WP_060433778.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
FR888_RS00870	184866..186065	+	1200	WP_055317090.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
FR888_RS00875	186101..186664	-	564	WP_047729417.1	DcrB family lipoprotein	-
FR888_RS00880	186745..187179	-	435	WP_047729416.1	GNAT family N-acetyltransferase	-
FR888_RS00885	187236..187895	-	660	WP_047729415.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
FR888_RS00890	188116..188361	+	246	WP_025304890.1	sulfurtransferase TusA	-
FR888_RS00895	188423..188620	+	198	WP_060433781.1	hypothetical protein	Antitoxin
FR888_RS00900	188620..188895	+	276	WP_048232401.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FR888_RS00905	188955..191273	-	2319	WP_048232403.1	zinc/cadmium/mercury/lead-transporting ATPase	-
FR888_RS00910	191956..193419	+	1464	WP_060433783.1	serralysin family metalloprotease	-
FR888_RS00915	193475..193852	+	378	WP_038874139.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10666.57 Da
• Isoelectric Point: 11.2806

>T135748 WP_048232401.1 NZ_CP042512:188620-188895 [Serratia marcescens]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKALIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T135748 NZ_CP042512:188620-188895 [Serratia marcescens]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7428.51 Da
• Isoelectric Point: 4.4143

>AT135748 WP_060433781.1 NZ_CP042512:188423-188620 [Serratia marcescens]
MSILLLPTVAKMENEERTQSYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Nucleotide

• Length: 198 bp

>AT135748 NZ_CP042512:188423-188620 [Serratia marcescens]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGAGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Structures

Toxin

• AlphaFold DB: A0A5P6GNV0