Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55864..56399 Replicon chromosome
Accession NZ_CP042512
Organism Serratia marcescens strain E28

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag FR888_RS00250 Protein ID WP_038875945.1
Coordinates 56124..56399 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5P6GNG1
Locus tag FR888_RS00245 Protein ID WP_038875948.1
Coordinates 55864..56124 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR888_RS00225 51184..51834 + 651 WP_047729554.1 DcrB-related protein -
FR888_RS00230 51875..52480 + 606 WP_047729552.1 glutathione S-transferase -
FR888_RS00235 52549..53943 + 1395 WP_060434098.1 L-seryl-tRNA(Sec) selenium transferase -
FR888_RS00240 53940..55781 + 1842 WP_060434100.1 selenocysteine-specific translation elongation factor -
FR888_RS00245 55864..56124 + 261 WP_038875948.1 ribbon-helix-helix domain-containing protein Antitoxin
FR888_RS00250 56124..56399 + 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR888_RS00255 56411..57322 - 912 WP_055311811.1 LysR family transcriptional regulator -
FR888_RS00260 57444..58070 + 627 WP_060434101.1 LysE family translocator -
FR888_RS00265 58123..59370 - 1248 WP_060434103.1 MFS transporter -
FR888_RS00270 59588..60580 + 993 WP_038875938.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T135747 WP_038875945.1 NZ_CP042512:56124-56399 [Serratia marcescens]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T135747 NZ_CP042512:56124-56399 [Serratia marcescens]
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9667.98 Da        Isoelectric Point: 4.5201

>AT135747 WP_038875948.1 NZ_CP042512:55864-56124 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT135747 NZ_CP042512:55864-56124 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A5P6GNG1

References