Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4390810..4391400 Replicon chromosome
Accession NZ_CP042499
Organism Enterobacter sp. E76

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag FR762_RS21295 Protein ID WP_125292343.1
Coordinates 4390810..4391142 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag FR762_RS21300 Protein ID WP_125292508.1
Coordinates 4391143..4391400 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR762_RS21275 4388539..4388883 - 345 WP_085802822.1 hypothetical protein -
FR762_RS21280 4389293..4390174 + 882 WP_085802821.1 hypothetical protein -
FR762_RS21285 4390315..4390452 - 138 Protein_4121 patatin -
FR762_RS21295 4390810..4391142 - 333 WP_125292343.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FR762_RS21300 4391143..4391400 - 258 WP_125292508.1 antitoxin Antitoxin
FR762_RS21305 4391614..4392090 - 477 WP_151605333.1 DUF1453 family protein -
FR762_RS21310 4392222..4393154 - 933 WP_125292345.1 L,D-transpeptidase -
FR762_RS21315 4393397..4394311 + 915 WP_151605334.1 metal ABC transporter substrate-binding protein -
FR762_RS21320 4394308..4395108 + 801 WP_151605335.1 manganese/iron ABC transporter ATP-binding protein -
FR762_RS21325 4395105..4395965 + 861 WP_151605336.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11839.66 Da        Isoelectric Point: 10.2966

>T135744 WP_125292343.1 NZ_CP042499:c4391142-4390810 [Enterobacter sp. E76]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSKASFNTFTRLPVVVPVTSGGHFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMVARSGKRLERIPEAIVNEVLARLEAILN

Download         Length: 333 bp

>T135744 NZ_CP042499:c4391142-4390810 [Enterobacter sp. E76]
ATGGACAGAGGCGAAATCTGGCTCGTTTCACTTGATCCCACTGCGGGCCATGAACAAAGCGGAAAGCGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAATACCTTTACCCGTCTGCCCGTTGTTGTTCCCGTTACCAGTGGCGGACACTTTGCCCGTG
CTGCGGGTTTTACCGTCTCACTGGACGGGGCCGGCACAAAAACAACGGGCGTCATTCGCTGTGACCAACCCAGAACCATT
GATATGGTAGCCAGGAGCGGCAAACGTCTGGAACGTATCCCCGAGGCGATAGTGAATGAAGTGCTGGCCAGGCTGGAAGC
TATTCTGAACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9372.94 Da        Isoelectric Point: 4.7862

>AT135744 WP_125292508.1 NZ_CP042499:c4391400-4391143 [Enterobacter sp. E76]
MYTTRLKKVGGSVMLTVPPAVLKTLGLTTDSEVGMTIDKGCLIIEAQKRPRYSLEELLAQCDPNAELSKEDREWIDAPPV
GKEIL

Download         Length: 258 bp

>AT135744 NZ_CP042499:c4391400-4391143 [Enterobacter sp. E76]
ATGTATACCACTCGCCTAAAAAAGGTCGGAGGATCTGTGATGCTTACGGTACCTCCCGCTGTGCTTAAAACGCTGGGTCT
AACGACGGACAGTGAAGTCGGTATGACTATTGATAAGGGCTGCCTGATTATTGAGGCCCAGAAACGGCCCCGTTATTCAC
TTGAGGAATTGTTGGCGCAGTGCGATCCCAACGCTGAACTGAGCAAAGAGGATCGAGAATGGATTGATGCACCGCCGGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References