Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2299034..2299561 Replicon chromosome
Accession NZ_CP042499
Organism Enterobacter sp. E76

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FR762_RS11015 Protein ID WP_151603695.1
Coordinates 2299286..2299561 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FR762_RS11010 Protein ID WP_151605614.1
Coordinates 2299034..2299282 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR762_RS10985 2294578..2295552 + 975 WP_151603690.1 UV damage endonuclease UvsE -
FR762_RS10990 2295539..2296720 - 1182 WP_125295098.1 purine ribonucleoside efflux pump NepI -
FR762_RS10995 2296831..2297763 - 933 WP_151603692.1 LysR family transcriptional regulator -
FR762_RS11000 2297863..2298297 + 435 WP_144129965.1 DMT family transporter -
FR762_RS11005 2298307..2298795 + 489 WP_151603694.1 DMT family transporter -
FR762_RS11010 2299034..2299282 + 249 WP_151605614.1 ribbon-helix-helix domain-containing protein Antitoxin
FR762_RS11015 2299286..2299561 + 276 WP_151603695.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR762_RS11020 2299622..2300548 - 927 WP_151603697.1 LysR family transcriptional regulator -
FR762_RS11025 2300720..2301670 + 951 WP_125295091.1 branched-chain amino acid ABC transporter permease -
FR762_RS11030 2301679..2302785 + 1107 WP_125295090.1 ABC transporter ATP-binding protein -
FR762_RS11035 2302782..2303549 + 768 WP_125295089.1 ABC transporter ATP-binding protein -
FR762_RS11040 2303542..2304261 + 720 WP_151603699.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11016.37 Da        Isoelectric Point: 5.5494

>T135732 WP_151603695.1 NZ_CP042499:2299286-2299561 [Enterobacter sp. E76]
MEIYWTHKAQDDLARIYRFAFQYSRQHATEVVDRLIASSADLTQHPAIGIQQTRYLPREVRKVLFDDYEIHYQIVENDIF
VLDLWSTREDR

Download         Length: 276 bp

>T135732 NZ_CP042499:2299286-2299561 [Enterobacter sp. E76]
ATGGAAATTTACTGGACGCATAAAGCTCAGGATGATCTGGCGCGGATTTATCGGTTTGCCTTTCAATATAGCCGCCAGCA
TGCAACAGAAGTCGTAGACCGGTTAATCGCTTCAAGCGCTGACCTTACCCAACATCCAGCAATCGGCATCCAGCAAACGC
GCTATCTTCCCAGGGAAGTAAGGAAGGTCTTGTTTGATGATTATGAAATTCATTATCAAATTGTGGAGAACGATATTTTT
GTACTCGATCTCTGGAGCACCAGAGAGGACAGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9124.43 Da        Isoelectric Point: 5.6882

>AT135732 WP_151605614.1 NZ_CP042499:2299034-2299282 [Enterobacter sp. E76]
MGSSTKQTISAQIPVELATAVEQLALELDRSKSWIIKEALTAMLAERERRHQSIQAGLDDVTEGRVISHAEMMNFASQLK
KE

Download         Length: 249 bp

>AT135732 NZ_CP042499:2299034-2299282 [Enterobacter sp. E76]
ATGGGTTCTTCAACCAAACAGACCATTAGCGCGCAAATTCCGGTGGAACTCGCTACTGCCGTTGAGCAGTTGGCACTTGA
ACTGGATCGGTCAAAAAGCTGGATTATCAAAGAAGCGCTTACTGCCATGCTGGCTGAAAGGGAGCGTCGGCATCAGAGCA
TTCAGGCGGGACTGGATGATGTTACTGAGGGCAGAGTGATTAGCCACGCAGAGATGATGAATTTTGCCAGTCAGTTGAAG
AAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References