Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 2265012..2265691 Replicon chromosome
Accession NZ_CP042499
Organism Enterobacter sp. E76

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag FR762_RS10855 Protein ID WP_151603639.1
Coordinates 2265012..2265353 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag FR762_RS10860 Protein ID WP_151603641.1
Coordinates 2265374..2265691 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR762_RS10830 2260932..2261174 + 243 WP_004883121.1 DUF2274 domain-containing protein -
FR762_RS10835 2261478..2262317 + 840 WP_192798696.1 MFS transporter -
FR762_RS10840 2262367..2263497 + 1131 WP_151603635.1 Gfo/Idh/MocA family oxidoreductase -
FR762_RS10845 2263494..2264393 + 900 WP_151603637.1 sugar phosphate isomerase/epimerase -
FR762_RS10855 2265012..2265353 - 342 WP_151603639.1 TA system toxin CbtA family protein Toxin
FR762_RS10860 2265374..2265691 - 318 WP_151603641.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FR762_RS10865 2265710..2265931 - 222 WP_151603643.1 DUF987 domain-containing protein -
FR762_RS10870 2265940..2266416 - 477 WP_151603645.1 RadC family protein -
FR762_RS10875 2266432..2266890 - 459 WP_151603647.1 antirestriction protein -
FR762_RS10880 2267149..2267496 - 348 WP_151603649.1 hypothetical protein -
FR762_RS10885 2267509..2268051 - 543 WP_151603651.1 hypothetical protein -
FR762_RS10890 2268113..2268802 - 690 WP_151603653.1 WYL domain-containing protein -
FR762_RS10895 2268995..2269885 - 891 WP_151603656.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12863.68 Da        Isoelectric Point: 8.0552

>T135731 WP_151603639.1 NZ_CP042499:c2265353-2265012 [Enterobacter sp. E76]
MKSQPAATSRAVKPCLSPEVVWQMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYGLVRNDRKGF
SWQEQSPYLRGVDILRARQATGLLKQSRNSEVR

Download         Length: 342 bp

>T135731 NZ_CP042499:c2265353-2265012 [Enterobacter sp. E76]
ATGAAATCTCAACCTGCAGCAACTTCGCGGGCGGTAAAGCCCTGCCTGTCACCCGAGGTAGTCTGGCAAATGCTACTGAC
ACACCTGCTTGAACAGCACTATGGTCTCACCCTCAACGACACACCATTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGCATCACGCTGGCTGATGCCGTGAACTTTCTGGTGGAAAAATACGGACTGGTGCGTAACGACAGGAAGGGATTT
AGCTGGCAGGAACAATCCCCTTATCTTCGGGGGGTAGATATTTTACGGGCGCGGCAGGCAACTGGCTTGTTGAAGCAAAG
CCGTAACAGCGAAGTACGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11997.71 Da        Isoelectric Point: 7.7477

>AT135731 WP_151603641.1 NZ_CP042499:c2265691-2265374 [Enterobacter sp. E76]
MSNTTWGLQRHITPRLGARLVQKGNRLHYLADRASITGKFSDPECRKLDETFPHFISQMELMLTTGELNPLYAHCITLYH
NSFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT135731 NZ_CP055109:c4589318-4589028 [Shigella flexneri]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References