Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1019810..1020360 Replicon chromosome
Accession NZ_CP042499
Organism Enterobacter sp. E76

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag FR762_RS04795 Protein ID WP_125292944.1
Coordinates 1019810..1020121 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag FR762_RS04800 Protein ID WP_125292827.1
Coordinates 1020124..1020360 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR762_RS04775 1015428..1015790 + 363 WP_151602859.1 YibL family ribosome-associated protein -
FR762_RS04780 1016129..1017784 + 1656 WP_151602861.1 L-lactate permease -
FR762_RS04785 1017781..1018563 + 783 WP_125292826.1 transcriptional regulator LldR -
FR762_RS04790 1018563..1019771 + 1209 WP_144132048.1 FMN-dependent L-lactate dehydrogenase LldD -
FR762_RS04795 1019810..1020121 - 312 WP_125292944.1 CcdB family protein Toxin
FR762_RS04800 1020124..1020360 - 237 WP_125292827.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FR762_RS04805 1020489..1021178 - 690 WP_192798685.1 6-N-hydroxylaminopurine resistance protein -
FR762_RS04810 1021248..1021868 - 621 WP_144131890.1 superoxide dismutase [Mn] -
FR762_RS04815 1022155..1023576 + 1422 WP_151602865.1 L-fucose/L-arabinose isomerase family protein -
FR762_RS04820 1023775..1024809 + 1035 WP_125292831.1 L-rhamnose/proton symporter RhaT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11526.58 Da        Isoelectric Point: 6.9759

>T135730 WP_125292944.1 NZ_CP042499:c1020121-1019810 [Enterobacter sp. E76]
MQFTVYKNTGRMALYPYVLNVQSDIIGRRTTRIVIPLFPLEKYMGPLADRLTPIVTVGPEKFVLMTHELASIPEKALGEE
ICSITSQRDVIKSALDFLLDGIG

Download         Length: 312 bp

>T135730 NZ_CP042499:c1020121-1019810 [Enterobacter sp. E76]
ATGCAATTTACGGTTTATAAAAATACCGGGCGAATGGCGCTTTATCCTTATGTTCTGAATGTACAGAGCGATATCATTGG
ACGCCGTACAACCCGGATTGTTATCCCGCTTTTTCCTTTAGAAAAGTACATGGGCCCTCTTGCAGACAGACTCACACCCA
TTGTGACGGTAGGACCTGAAAAGTTTGTGTTAATGACTCACGAACTCGCGAGTATTCCTGAAAAAGCGCTGGGTGAAGAA
ATCTGTAGCATCACGAGCCAACGTGATGTCATTAAATCAGCGTTGGATTTTCTGCTGGATGGGATCGGTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8859.98 Da        Isoelectric Point: 7.2018

>AT135730 WP_125292827.1 NZ_CP042499:c1020360-1020124 [Enterobacter sp. E76]
MPALKRNKKTVTVTAAPELIQEAKAHGVNLSQTFENAIRAELHSIQVARWQKDNAQAIDYLNKLSEENGLFSDEYRTF

Download         Length: 237 bp

>AT135730 NZ_CP042499:c1020360-1020124 [Enterobacter sp. E76]
ATGCCCGCTCTTAAACGAAATAAAAAGACGGTTACAGTAACCGCAGCTCCTGAATTGATTCAGGAAGCCAAAGCGCACGG
CGTCAATTTATCTCAGACGTTTGAAAATGCAATACGTGCCGAACTGCATAGCATTCAGGTTGCTCGCTGGCAGAAGGATA
ACGCGCAGGCCATTGATTATCTGAATAAACTTTCAGAGGAGAACGGTCTGTTCTCCGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References