Detailed information of TA system TA135723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2915723..2916334
• Replicon: chromosome
• Accession: NZ_CP042488
• Organism: Enterobacter hormaechei strain C15

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: FR808_RS14190
• Protein ID: WP_012906750.1
• Coordinates: 2915723..2915902 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FR808_RS14195
• Protein ID: WP_047737705.1
• Coordinates: 2915924..2916334 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR808_RS14155	2911123..2911839	+	717	WP_003859661.1	ABC transporter ATP-binding protein	-
FR808_RS14160	2912003..2912473	+	471	WP_003859658.1	hypothetical protein	-
FR808_RS14165	2912479..2913405	-	927	WP_022651459.1	LysR family transcriptional regulator	-
FR808_RS14170	2913435..2913758	-	324	WP_003859653.1	hypothetical protein	-
FR808_RS25520	2914446..2914730	+	285	WP_072060371.1	ash family protein	-
FR808_RS14185	2914642..2915238	+	597	WP_047737708.1	Rha family transcriptional regulator	-
FR808_RS14190	2915723..2915902	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
FR808_RS14195	2915924..2916334	+	411	WP_047737705.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FR808_RS14200	2916416..2916982	+	567	WP_058691493.1	serine acetyltransferase	-
FR808_RS14205	2916986..2917408	-	423	WP_063842524.1	tail fiber assembly protein	-
FR808_RS14210	2918490..2919551	-	1062	Protein_2742	phage tail protein	-
FR808_RS14215	2919554..2920105	-	552	WP_045345258.1	phage tail protein I	-
FR808_RS14220	2920098..2921012	-	915	WP_058691495.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliA	2911135..2966157	55022

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T135723 WP_012906750.1 NZ_CP042488:2915723-2915902 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T135723 NZ_CP042488:2915723-2915902 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTGACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATAA
AAAAACAGGCGGGGCTCTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14874.84 Da
• Isoelectric Point: 4.3793

>AT135723 WP_047737705.1 NZ_CP042488:2915924-2916334 [Enterobacter hormaechei]
MLYPVAIDKGVSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT135723 NZ_CP042488:2915924-2916334 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGTTTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCTCACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCAGAAGCAACGACCGTCGAAAACTGGCTTTCTGATCCGGAGTACGCCGGTGCGGTCTGGGCCTTGGTAGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATTAATGTGACGCTTCCCTCATTGCTGATCCGTCGTATCGATCA
GTTCGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGACAAAGTAATTGGACGAG
AAAAACGATAA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4