Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1165161..1165781 Replicon chromosome
Accession NZ_CP042488
Organism Enterobacter hormaechei strain C15

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FR808_RS05625 Protein ID WP_015571250.1
Coordinates 1165161..1165379 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FR808_RS05630 Protein ID WP_006809850.1
Coordinates 1165407..1165781 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR808_RS05595 1161173..1161433 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FR808_RS05600 1161436..1161576 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FR808_RS05605 1161573..1162283 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
FR808_RS05610 1162385..1163845 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
FR808_RS05615 1163817..1164284 - 468 WP_022650495.1 hypothetical protein -
FR808_RS05620 1164401..1164952 - 552 WP_022650496.1 maltose O-acetyltransferase -
FR808_RS05625 1165161..1165379 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FR808_RS05630 1165407..1165781 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FR808_RS05635 1166292..1169438 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
FR808_RS05640 1169461..1170654 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T135712 WP_015571250.1 NZ_CP042488:c1165379-1165161 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T135712 NZ_CP042488:c1165379-1165161 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT135712 WP_006809850.1 NZ_CP042488:c1165781-1165407 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT135712 NZ_CP042488:c1165781-1165407 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGCCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References