Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 665959..666662 Replicon chromosome
Accession NZ_CP042488
Organism Enterobacter hormaechei strain C15

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8B5ZZ18
Locus tag FR808_RS03255 Protein ID WP_039268718.1
Coordinates 666321..666662 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B5ZWQ9
Locus tag FR808_RS03250 Protein ID WP_039268717.1
Coordinates 665959..666300 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR808_RS03215 661112..661987 + 876 WP_039268712.1 GTPase family protein -
FR808_RS03220 662231..662947 + 717 WP_039268713.1 WYL domain-containing protein -
FR808_RS03225 662983..663435 + 453 WP_039269148.1 hypothetical protein -
FR808_RS03230 663507..663980 + 474 WP_039268714.1 hypothetical protein -
FR808_RS03235 664101..664922 + 822 WP_039268715.1 DUF945 domain-containing protein -
FR808_RS03240 664953..665393 + 441 WP_039268716.1 antirestriction protein -
FR808_RS03245 665406..665948 + 543 WP_045259572.1 DNA repair protein RadC -
FR808_RS03250 665959..666300 + 342 WP_039268717.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FR808_RS03255 666321..666662 + 342 WP_039268718.1 TA system toxin CbtA family protein Toxin
FR808_RS03260 666917..667924 + 1008 WP_039268719.1 restriction endonuclease -
FR808_RS03270 668105..668941 - 837 Protein_623 HNH endonuclease -
FR808_RS03275 669241..669708 + 468 WP_022650322.1 SymE family type I addiction module toxin -
FR808_RS03280 669766..670137 - 372 WP_022650323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 626613..674608 47995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12772.83 Da        Isoelectric Point: 9.6548

>T135711 WP_039268718.1 NZ_CP042488:666321-666662 [Enterobacter hormaechei]
MKTLPATTPQAAKLCLLPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T135711 NZ_CP042488:666321-666662 [Enterobacter hormaechei]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATGTCTGTTGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACGCCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCTTATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12729.40 Da        Isoelectric Point: 6.9460

>AT135711 WP_039268717.1 NZ_CP042488:665959-666300 [Enterobacter hormaechei]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGGMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT135711 NZ_CP042488:665959-666300 [Enterobacter hormaechei]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTAGCTGACCGGGTCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGGAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5ZZ18

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5ZWQ9

References