Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 298084..298680 Replicon chromosome
Accession NZ_CP042488
Organism Enterobacter hormaechei strain C15

Toxin (Protein)


Gene name PumA Uniprot ID A0A5D9Q9B8
Locus tag FR808_RS01430 Protein ID WP_003860348.1
Coordinates 298378..298680 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag FR808_RS01425 Protein ID WP_022650216.1
Coordinates 298084..298371 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR808_RS01420 296456..298087 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
FR808_RS01425 298084..298371 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
FR808_RS01430 298378..298680 - 303 WP_003860348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR808_RS01435 298878..299750 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
FR808_RS01440 299751..300023 - 273 WP_003860346.1 DUF3811 domain-containing protein -
FR808_RS01445 300074..301018 - 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
FR808_RS01450 301112..302461 - 1350 WP_003860344.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11393.20 Da        Isoelectric Point: 10.1042

>T135709 WP_003860348.1 NZ_CP042488:c298680-298378 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHLGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T135709 NZ_CP042488:c298680-298378 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTGGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT135709 WP_022650216.1 NZ_CP042488:c298371-298084 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT135709 NZ_CP042488:c298371-298084 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9Q9B8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References