Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 150205..150727 | Replicon | plasmid pC51_001 |
Accession | NZ_CP042482 | ||
Organism | Klebsiella pneumoniae strain C51 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A4R0GPV2 |
Locus tag | FR751_RS26430 | Protein ID | WP_032731992.1 |
Coordinates | 150443..150727 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | A0A2J4ZSR4 |
Locus tag | FR751_RS26425 | Protein ID | WP_004187025.1 |
Coordinates | 150205..150453 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FR751_RS26410 | 145623..146756 | - | 1134 | WP_022651297.1 | glutathione-independent formaldehyde dehydrogenase | - |
FR751_RS26415 | 147215..148813 | - | 1599 | WP_050597293.1 | sensor domain-containing diguanylate cyclase | - |
FR751_RS26420 | 149037..149960 | + | 924 | WP_032731993.1 | IS5 family transposase | - |
FR751_RS26425 | 150205..150453 | + | 249 | WP_004187025.1 | plasmid stabilization protein | Antitoxin |
FR751_RS26430 | 150443..150727 | + | 285 | WP_032731992.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FR751_RS26435 | 150962..151620 | + | 659 | Protein_150 | IS1 family transposase | - |
FR751_RS26440 | 151669..152652 | - | 984 | Protein_151 | IS630 family transposase | - |
FR751_RS26445 | 153007..153384 | + | 378 | Protein_152 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | formA | cheD | 1..216942 | 216942 | |
- | inside | IScluster/Tn | formA | cheD | 130494..160726 | 30232 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11017.75 Da Isoelectric Point: 10.5388
>T135705 WP_032731992.1 NZ_CP042482:150443-150727 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGIGK
RENDDIYNATLNRN
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGIGK
RENDDIYNATLNRN
Download Length: 285 bp
>T135705 NZ_CP042482:150443-150727 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCGCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAGCTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCATAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTAA
ATGACCTATAAGCTGGCTTTCAACGAATCCGCGCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAGCTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCATAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9011.24 Da Isoelectric Point: 3.9947
>AT135705 WP_004187025.1 NZ_CP042482:150205-150453 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL
Download Length: 249 bp
>AT135705 NZ_CP042482:150205-150453 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4R0GPV2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZSR4 |