135699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4740492..4741149 Replicon chromosome
Accession NZ_CP042481
Organism Klebsiella pneumoniae strain C51

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FR751_RS23165 Protein ID WP_002916310.1
Coordinates 4740492..4740902 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FR751_RS23170 Protein ID WP_002916312.1
Coordinates 4740883..4741149 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR751_RS23145 4736492..4738225 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
FR751_RS23150 4738231..4738944 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FR751_RS23155 4738967..4739863 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FR751_RS23160 4739964..4740485 + 522 WP_004144730.1 flavodoxin FldB -
FR751_RS23165 4740492..4740902 - 411 WP_002916310.1 protein YgfX Toxin
FR751_RS23170 4740883..4741149 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FR751_RS23175 4741395..4742378 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
FR751_RS23180 4742529..4743188 - 660 WP_002916317.1 hemolysin III family protein -
FR751_RS23185 4743352..4743663 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FR751_RS23190 4743713..4744441 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FR751_RS23195 4744560..4745993 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T135699 WP_002916310.1 NZ_CP042481:c4740902-4740492 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T135699 NZ_CP042481:c4740902-4740492 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGTCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT135699 WP_002916312.1 NZ_CP042481:c4741149-4740883 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT135699 NZ_CP042481:c4741149-4740883 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References