135687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 911896..912412 Replicon chromosome
Accession NZ_CP042481
Organism Klebsiella pneumoniae strain C51

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag FR751_RS04350 Protein ID WP_009309309.1
Coordinates 912128..912412 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FR751_RS04345 Protein ID WP_002886901.1
Coordinates 911896..912138 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR751_RS04330 907936..908676 + 741 WP_002886899.1 KDGP aldolase family protein -
FR751_RS04335 908743..909897 + 1155 WP_002886900.1 lactonase family protein -
FR751_RS04340 909920..911818 + 1899 WP_040088020.1 BglG family transcription antiterminator -
FR751_RS04345 911896..912138 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FR751_RS04350 912128..912412 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR751_RS04355 912416..912880 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FR751_RS04360 913122..915260 - 2139 WP_040088018.1 anaerobic ribonucleoside-triphosphate reductase -
FR751_RS04365 915617..916360 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FR751_RS28320 916363..916536 - 174 WP_004146781.1 hypothetical protein -
FR751_RS04370 916621..916929 + 309 WP_016947038.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T135687 WP_009309309.1 NZ_CP042481:912128-912412 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T135687 NZ_CP042481:912128-912412 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT135687 WP_002886901.1 NZ_CP042481:911896-912138 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT135687 NZ_CP042481:911896-912138 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References