Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 219136..220704 Replicon plasmid pC50_001
Accession NZ_CP042479
Organism Citrobacter freundii strain C50

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FR753_RS26180 Protein ID WP_151532702.1
Coordinates 219397..220704 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FR753_RS26175 Protein ID WP_012766359.1
Coordinates 219136..219387 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR753_RS26145 215306..215758 + 453 WP_057521240.1 hypothetical protein -
FR753_RS26150 215774..216376 - 603 WP_057521239.1 hypothetical protein -
FR753_RS26155 216640..216908 + 269 Protein_237 hypothetical protein -
FR753_RS26165 217218..217748 + 531 WP_057521237.1 hypothetical protein -
FR753_RS26170 217751..218755 + 1005 WP_012766358.1 tyrosine-type recombinase/integrase -
FR753_RS26175 219136..219387 + 252 WP_012766359.1 helix-turn-helix domain-containing protein Antitoxin
FR753_RS26180 219397..220704 + 1308 WP_151532702.1 type II toxin-antitoxin system HipA family toxin Toxin
FR753_RS26185 220701..221195 + 495 WP_057521236.1 hypothetical protein -
FR753_RS26190 221370..222308 - 939 WP_057521235.1 hypothetical protein -
FR753_RS26195 222507..224147 + 1641 WP_057521234.1 PAAR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid formA - 1..243455 243455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47840.99 Da        Isoelectric Point: 6.1142

>T135682 WP_151532702.1 NZ_CP042479:219397-220704 [Citrobacter freundii]
MQTLTVAMNGEAVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRFAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYSFAMIQPRHFISTAAHVGFPPDTAAQLMLDMATKTEEVVA
TVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK

Download         Length: 1308 bp

>T135682 NZ_CP042479:219397-220704 [Citrobacter freundii]
ATGCAGACGCTAACAGTGGCGATGAATGGTGAGGCCGTAGGCACACTGTACCGAGATAACAAAGGGGCCATGTCATTTCA
GTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCTATTTCCATGTCACTGCCTTTGGGTCATGGCAGGATCACAG
GAAGTGAAGTTTTCAATTTCTTTAGCAACCTCCTACCTGACTCAGAGGCAATTATTGCCAGGATGCAGGCCCGGTTCAGA
GTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGACTGTGTTGGAGCTATCCAGCTCTATTCCCCCGA
TGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAGGCTACC
AGGAAGCTCCCCTTGGGATGGCTGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCACTGCTT
TGGTATCAGGATCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAAGATTGT
TCAAAATAACATCGATCTCAGTGAGAGTTGCGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTTTTGACG
TCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTAGTTCAGCGTTTTGACCGGCGCTGGTCTAAATCC
GGCGAATGGCTTCTGCGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATATGAGTCACA
TGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGATTTGCGGCCAAGGATAGAGAGCAATTTTTCA
AGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATTTTCATTGAGCCTGCATCG
TCATTTAGGATGACACCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCAAAAGGC
AAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACAGTTTTGCGATGATCCAGCCTCGTCATTTTATCAGTACCG
CCGCCCATGTCGGGTTCCCACCAGATACCGCAGCTCAACTCATGCTCGACATGGCTACCAAGACAGAGGAGGTGGTTGCC
ACAGTAGCGGCTGAGCTACCAGCCGGTTTCCCAGAGCACATCAGTAGTGCCATCTTCGAGGGGCTGTCCAGCCAGGCGGC
TAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9380.82 Da        Isoelectric Point: 9.8930

>AT135682 WP_012766359.1 NZ_CP042479:219136-219387 [Citrobacter freundii]
MKVTSPSLLAAAVRDQRKLSKLTQSEAAKQVGIKQTTVSDFELRPESTKLETLFKLLAALDLELHVVKRGSTLDDNKVWD
REW

Download         Length: 252 bp

>AT135682 NZ_CP042479:219136-219387 [Citrobacter freundii]
ATGAAAGTGACATCTCCATCCTTACTTGCGGCTGCGGTGCGCGACCAACGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTGCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAATAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References