Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 287752..288383 Replicon chromosome
Accession NZ_CP042478
Organism Citrobacter freundii strain C50

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag FR753_RS01415 Protein ID WP_003837806.1
Coordinates 287752..288027 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag FR753_RS01420 Protein ID WP_003837808.1
Coordinates 288024..288383 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR753_RS01405 283803..286550 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
FR753_RS01410 286550..287674 + 1125 WP_003837801.1 ABC transporter permease -
FR753_RS01415 287752..288027 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
FR753_RS01420 288024..288383 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FR753_RS01425 288496..288897 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
FR753_RS01430 288947..289525 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
FR753_RS01435 289588..290637 - 1050 WP_003023393.1 AI-2E family transporter -
FR753_RS01440 290771..291988 + 1218 WP_016151126.1 MFS transporter -
FR753_RS01445 291992..292549 - 558 WP_003837816.1 DcrB family lipoprotein -
FR753_RS01450 292622..293287 - 666 WP_119174639.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T135664 WP_003837806.1 NZ_CP042478:287752-288027 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T135664 NZ_CP042478:287752-288027 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT135664 WP_003837808.1 NZ_CP042478:288024-288383 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT135664 NZ_CP042478:288024-288383 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References