Detailed information of TA system TA135660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 490456..491084
• Replicon: chromosome
• Accession: NZ_CP042466
• Organism: Geobacter sp. FeAm09

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FO488_RS02270
• Protein ID: WP_205743332.1
• Coordinates: 490686..491084 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FO488_RS02265
• Protein ID: WP_149209043.1
• Coordinates: 490456..490686 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO488_RS02240	486635..487369	+	735	WP_149209039.1	hypothetical protein	-
FO488_RS02245	487373..487954	+	582	WP_149209040.1	protein kinase	-
FO488_RS02255	488237..489430	+	1194	WP_149209041.1	hypothetical protein	-
FO488_RS02260	489432..490151	+	720	WP_149209042.1	protein phosphatase 2C domain-containing protein	-
FO488_RS02265	490456..490686	+	231	WP_149209043.1	antitoxin	Antitoxin
FO488_RS02270	490686..491084	+	399	WP_205743332.1	PIN domain-containing protein	Toxin
FO488_RS02275	491233..492603	+	1371	WP_149209045.1	polynucleotide adenylyltransferase PcnB	-
FO488_RS02280	492769..493791	+	1023	WP_149209046.1	alpha/beta hydrolase	-
FO488_RS02285	493788..494012	-	225	WP_149209047.1	hypothetical protein	-
FO488_RS02290	494369..494989	+	621	WP_149209048.1	hypothetical protein	-
FO488_RS02295	495194..495532	+	339	WP_168205839.1	PilZ domain-containing protein	-
FO488_RS02300	495597..496031	-	435	WP_149209050.1	universal stress protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14614.88 Da
• Isoelectric Point: 6.6325

>T135660 WP_205743332.1 NZ_CP042466:490686-491084 [Geobacter sp. FeAm09]
MRYMLDTNICSYILKSHPAAVRQKFEEVGPENICISSIVLAELYYGAVRHPKGVVIRHEIDDFAARLIVLPWDEAAADHY
GAIRVSLEKAGTLVGAMDMLIAAHAKSCGATLVSNNLREFDRIKSLETANWA

Nucleotide

• Length: 399 bp

>T135660 NZ_CP042466:490686-491084 [Geobacter sp. FeAm09]
ATGCGGTATATGCTCGATACCAACATATGCAGCTACATCCTCAAGAGCCATCCTGCGGCGGTCAGGCAGAAGTTTGAAGA
GGTCGGCCCCGAAAACATCTGTATATCCTCAATCGTCCTCGCCGAGCTGTACTACGGCGCGGTCCGGCACCCAAAGGGCG
TTGTTATCCGCCACGAGATTGACGATTTCGCGGCCAGGTTGATCGTGTTGCCGTGGGATGAAGCGGCTGCCGATCACTAT
GGGGCGATCCGGGTGTCTCTGGAGAAGGCTGGTACCCTCGTAGGAGCGATGGATATGCTGATAGCGGCGCACGCCAAAAG
CTGCGGCGCCACACTGGTGTCCAACAACCTGCGGGAATTCGACCGGATCAAAAGCCTGGAAACGGCTAATTGGGCATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8845.06 Da
• Isoelectric Point: 8.8546

>AT135660 WP_149209043.1 NZ_CP042466:490456-490686 [Geobacter sp. FeAm09]
MNRVAKIFQNGRSQAVRLPAEFRFSTHEVFIERQGDAIVLRPKPESWDDFFARPSKVPADFLADRKDVPPEARELF

Nucleotide

• Length: 231 bp

>AT135660 NZ_CP042466:490456-490686 [Geobacter sp. FeAm09]
ATGAATAGAGTCGCTAAAATATTCCAAAACGGCCGGAGCCAGGCAGTACGCCTCCCAGCAGAATTCCGTTTTTCCACTCA
TGAGGTCTTTATCGAACGCCAGGGGGACGCCATCGTACTCAGGCCCAAGCCCGAGAGTTGGGACGACTTTTTTGCCCGGC
CGTCCAAGGTACCGGCTGACTTTCTTGCCGACCGGAAAGACGTGCCGCCTGAAGCAAGAGAGCTGTTTTGA