Detailed information of TA system TA135657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 31670..32288
• Replicon: chromosome
• Accession: NZ_CP042466
• Organism: Geobacter sp. FeAm09

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FO488_RS00200
• Protein ID: WP_149208674.1
• Coordinates: 32100..32288 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FO488_RS00195
• Protein ID: WP_149208673.1
• Coordinates: 31670..32086 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO488_RS00160	26785..27075	+	291	WP_149208666.1	helix-turn-helix transcriptional regulator	-
FO488_RS19225	27158..27319	+	162	WP_168205806.1	hypothetical protein	-
FO488_RS00165	27714..28250	+	537	WP_149208667.1	lytic transglycosylase domain-containing protein	-
FO488_RS00170	28275..28994	+	720	WP_149208668.1	DUF2786 domain-containing protein	-
FO488_RS00175	29038..29649	+	612	WP_149208669.1	hypothetical protein	-
FO488_RS00180	29650..30282	+	633	WP_149208670.1	hypothetical protein	-
FO488_RS00185	30284..30658	+	375	WP_149208671.1	TSCPD domain-containing protein	-
FO488_RS00190	30648..31529	+	882	WP_149208672.1	radical SAM protein	-
FO488_RS00195	31670..32086	-	417	WP_149208673.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FO488_RS00200	32100..32288	-	189	WP_149208674.1	type II toxin-antitoxin system HicA family toxin	Toxin
FO488_RS00205	32923..35784	+	2862	WP_149208675.1	relaxase domain-containing protein	-
FO488_RS00210	35804..36037	+	234	WP_149208676.1	hypothetical protein	-
FO488_RS00215	36027..36257	+	231	WP_149208677.1	hypothetical protein	-
FO488_RS00220	36564..37130	+	567	WP_149208678.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1160..166139	164979

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6856.11 Da
• Isoelectric Point: 10.7142

>T135657 WP_149208674.1 NZ_CP042466:c32288-32100 [Geobacter sp. FeAm09]
MNSAEMKRWLEKQGCTFEAKKGGGGHLIVKLGDRKSELPMHGHGRELKKGLVEGVKKQLGLK

Nucleotide

• Length: 189 bp

>T135657 NZ_CP042466:c32288-32100 [Geobacter sp. FeAm09]
ATGAACAGCGCCGAAATGAAAAGATGGTTGGAGAAACAAGGATGCACCTTCGAGGCAAAGAAGGGCGGTGGCGGCCATCT
GATCGTGAAACTCGGCGACCGCAAGAGCGAACTGCCGATGCATGGACATGGCAGAGAGTTGAAAAAGGGCTTGGTTGAGG
GTGTCAAAAAGCAACTCGGCCTGAAATAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15168.61 Da
• Isoelectric Point: 4.6456

>AT135657 WP_149208673.1 NZ_CP042466:c32086-31670 [Geobacter sp. FeAm09]
VLAYPVHLEPAEEGGFVVTFPDIPEAITEGDDETEALVWAQDALETMLESYMDDRQRIPYPSPANGRPVVVLPVVAAGKV
ILHNTMLDAGKKKADLARMLNLAPTLVDRLLSLRHKSRIEQIETALAIFGKKLVVDVI

Nucleotide

• Length: 417 bp

>AT135657 NZ_CP042466:c32086-31670 [Geobacter sp. FeAm09]
GTGTTGGCATATCCCGTACATCTCGAACCTGCTGAAGAAGGCGGGTTTGTGGTTACTTTTCCCGACATTCCCGAGGCGAT
CACCGAGGGAGATGATGAAACCGAGGCTCTCGTTTGGGCACAGGACGCTCTCGAAACCATGCTGGAATCGTATATGGACG
ATCGGCAACGTATTCCATATCCGTCTCCGGCCAATGGACGCCCTGTTGTTGTGCTGCCGGTCGTAGCTGCCGGCAAAGTG
ATCCTGCACAACACCATGTTGGACGCTGGCAAAAAGAAAGCGGATCTCGCACGTATGTTGAACCTGGCTCCCACTCTGGT
GGACCGACTTCTGTCTCTGCGGCACAAGAGCCGGATCGAGCAGATCGAGACAGCGTTGGCGATTTTCGGAAAGAAGCTTG
TGGTTGATGTCATCTGA