Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1571641..1572200 Replicon chromosome
Accession NZ_CP042449
Organism Vibrio alginolyticus strain FA2

Toxin (Protein)


Gene name relE Uniprot ID A0A2K7SRU8
Locus tag FR729_RS07260 Protein ID WP_017035198.1
Coordinates 1571922..1572200 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag FR729_RS07255 Protein ID WP_005398409.1
Coordinates 1571641..1571925 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR729_RS07200 1567403..1567495 - 93 WP_079400729.1 DUF3265 domain-containing protein -
FR729_RS07205 1567510..1568049 - 540 WP_167415285.1 hypothetical protein -
FR729_RS07210 1568078..1568170 - 93 WP_198912768.1 DUF3265 domain-containing protein -
FR729_RS07215 1568185..1568775 - 591 WP_174844517.1 GNAT family N-acetyltransferase -
FR729_RS07220 1569314..1569430 - 117 WP_167415699.1 DUF3265 domain-containing protein -
FR729_RS07225 1569427..1570125 - 699 WP_114321680.1 hypothetical protein -
FR729_RS07230 1570172..1570264 - 93 WP_079853721.1 DUF3265 domain-containing protein -
FR729_RS07235 1570290..1570706 - 417 WP_065771552.1 GNAT family N-acetyltransferase -
FR729_RS07240 1570751..1570843 - 93 WP_193244088.1 DUF3265 domain-containing protein -
FR729_RS07245 1570858..1571442 - 585 WP_167415287.1 hypothetical protein -
FR729_RS07250 1571473..1571564 - 92 Protein_1408 DUF3265 domain-containing protein -
FR729_RS07255 1571641..1571925 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FR729_RS07260 1571922..1572200 + 279 WP_017035198.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FR729_RS07265 1572229..1572321 - 93 WP_198912769.1 DUF3265 domain-containing protein -
FR729_RS07270 1572347..1572808 - 462 WP_104027849.1 hypothetical protein -
FR729_RS07275 1572822..1573097 - 276 WP_130241647.1 hypothetical protein -
FR729_RS07280 1573125..1573217 - 93 WP_198912770.1 DUF3265 domain-containing protein -
FR729_RS07285 1573232..1573645 - 414 WP_167415288.1 hypothetical protein -
FR729_RS07290 1573801..1573893 - 93 WP_198912771.1 DUF3265 domain-containing protein -
FR729_RS07295 1573908..1574231 - 324 WP_077200549.1 hypothetical protein -
FR729_RS07300 1574259..1574351 - 93 WP_080374080.1 DUF3265 domain-containing protein -
FR729_RS07305 1574377..1574739 - 363 WP_005386966.1 VOC family protein -
FR729_RS07310 1574792..1574938 - 147 WP_080277001.1 DUF3265 domain-containing protein -
FR729_RS07315 1574913..1575185 - 273 WP_005462157.1 nicotinamide mononucleotide transporter -
FR729_RS07320 1575722..1575814 - 93 WP_079749986.1 DUF3265 domain-containing protein -
FR729_RS07325 1575829..1576173 - 345 WP_025638209.1 hypothetical protein -
FR729_RS07330 1576206..1576298 - 93 WP_198912772.1 DUF3265 domain-containing protein -
FR729_RS07335 1576324..1576782 - 459 WP_167415289.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1514574..1605716 91142
- inside Integron - - 1522757..1604598 81841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T135656 WP_017035198.1 NZ_CP042449:1571922-1572200 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T135656 NZ_CP042449:1571922-1572200 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGGGTACAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT135656 WP_005398409.1 NZ_CP042449:1571641-1571925 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT135656 NZ_CP042449:1571641-1571925 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTTGTTGAGCATCAAACGGCTAAGTCTCGG
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References