Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1557860..1558388 Replicon chromosome
Accession NZ_CP042449
Organism Vibrio alginolyticus strain FA2

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag FR729_RS07120 Protein ID WP_005377002.1
Coordinates 1558098..1558388 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag FR729_RS07115 Protein ID WP_005377003.1
Coordinates 1557860..1558108 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR729_RS07060 1553124..1553531 - 408 WP_031781085.1 hypothetical protein -
FR729_RS07065 1553676..1554023 - 348 WP_025793492.1 DNA-binding protein -
FR729_RS07070 1554051..1554140 - 90 WP_079390637.1 DUF3265 domain-containing protein -
FR729_RS07075 1554167..1554526 - 360 WP_025523617.1 hypothetical protein -
FR729_RS07080 1554546..1554677 - 132 WP_005536196.1 DUF3265 domain-containing protein -
FR729_RS07085 1555166..1555258 - 93 WP_064490370.1 DUF3265 domain-containing protein -
FR729_RS07090 1555636..1556121 - 486 WP_005382557.1 type VI secretion system amidase effector protein Tae4 -
FR729_RS07095 1556262..1556354 - 93 WP_192947860.1 DUF3265 domain-containing protein -
FR729_RS07100 1556392..1557030 - 639 WP_005382559.1 class I SAM-dependent methyltransferase -
FR729_RS07105 1557051..1557143 - 93 WP_005534950.1 DUF3265 domain-containing protein -
FR729_RS07110 1557173..1557643 - 471 WP_005386960.1 GNAT family N-acetyltransferase -
FR729_RS24070 1557717..1557785 - 69 WP_074531725.1 DUF3265 domain-containing protein -
FR729_RS07115 1557860..1558108 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FR729_RS07120 1558098..1558388 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR729_RS07125 1558407..1558499 - 93 WP_140073894.1 DUF3265 domain-containing protein -
FR729_RS07130 1558514..1559011 - 498 WP_167415693.1 GNAT family N-acetyltransferase -
FR729_RS24075 1558991..1559102 - 112 Protein_1384 nitrate reductase -
FR729_RS07135 1559159..1560286 - 1128 WP_167415694.1 DUF3800 domain-containing protein -
FR729_RS07140 1560394..1561119 - 726 WP_167415281.1 hypothetical protein -
FR729_RS07145 1561156..1561272 - 117 WP_167415695.1 DUF3265 domain-containing protein -
FR729_RS07150 1561269..1561877 - 609 WP_167415282.1 hypothetical protein -
FR729_RS07155 1561929..1562780 - 852 WP_167415268.1 IS3 family transposase -
FR729_RS07160 1562864..1563085 - 222 Protein_1390 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1514574..1605716 91142
- inside Integron - - 1522757..1604598 81841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T135655 WP_005377002.1 NZ_CP042449:1558098-1558388 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T135655 NZ_CP042449:1558098-1558388 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTATCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT135655 WP_005377003.1 NZ_CP042449:1557860-1558108 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT135655 NZ_CP042449:1557860-1558108 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTAAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References