Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1532429..1532976 | Replicon | chromosome |
| Accession | NZ_CP042449 | ||
| Organism | Vibrio alginolyticus strain FA2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | FR729_RS06825 | Protein ID | WP_167415266.1 |
| Coordinates | 1532429..1532731 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | FR729_RS06830 | Protein ID | WP_005448240.1 |
| Coordinates | 1532719..1532976 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FR729_RS06760 | 1528143..1528691 | - | 549 | WP_025502382.1 | hypothetical protein | - |
| FR729_RS06765 | 1528732..1528821 | - | 90 | WP_077345960.1 | DUF3265 domain-containing protein | - |
| FR729_RS06770 | 1528839..1529252 | - | 414 | WP_167415263.1 | hypothetical protein | - |
| FR729_RS06775 | 1529333..1529425 | - | 93 | WP_079858460.1 | DUF3265 domain-containing protein | - |
| FR729_RS06780 | 1529449..1529970 | - | 522 | WP_167415264.1 | hypothetical protein | - |
| FR729_RS06785 | 1529995..1530105 | - | 111 | WP_081053587.1 | DUF3265 domain-containing protein | - |
| FR729_RS06790 | 1530102..1530425 | - | 324 | WP_054866683.1 | hypothetical protein | - |
| FR729_RS06795 | 1530592..1531116 | - | 525 | WP_029785320.1 | DUF4823 domain-containing protein | - |
| FR729_RS06800 | 1531188..1531280 | - | 93 | WP_079878770.1 | DUF3265 domain-containing protein | - |
| FR729_RS06805 | 1531315..1531716 | - | 402 | WP_054577320.1 | HIT family protein | - |
| FR729_RS06810 | 1531749..1531838 | - | 90 | WP_072609598.1 | DUF3265 domain-containing protein | - |
| FR729_RS06815 | 1531867..1532274 | - | 408 | WP_167415265.1 | hypothetical protein | - |
| FR729_RS06820 | 1532301..1532393 | - | 93 | WP_198912765.1 | DUF3265 domain-containing protein | - |
| FR729_RS06825 | 1532429..1532731 | - | 303 | WP_167415266.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FR729_RS06830 | 1532719..1532976 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FR729_RS06835 | 1533058..1533150 | - | 93 | WP_115386120.1 | DUF3265 domain-containing protein | - |
| FR729_RS06840 | 1533172..1533507 | - | 336 | WP_031780757.1 | energy transducer TonB | - |
| FR729_RS06845 | 1534195..1534605 | - | 411 | WP_167415267.1 | cytidine deaminase | - |
| FR729_RS06850 | 1534668..1535519 | - | 852 | WP_167415268.1 | IS3 family transposase | - |
| FR729_RS06855 | 1535603..1535824 | - | 222 | Protein_1327 | transposase | - |
| FR729_RS06860 | 1535906..1535995 | - | 90 | WP_072611848.1 | DUF3265 domain-containing protein | - |
| FR729_RS06865 | 1536024..1536350 | - | 327 | WP_139794022.1 | hypothetical protein | - |
| FR729_RS06870 | 1536393..1536484 | - | 92 | Protein_1330 | DUF3265 domain-containing protein | - |
| FR729_RS06875 | 1536939..1537031 | - | 93 | WP_167415270.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1514574..1605716 | 91142 | |
| - | inside | Integron | - | - | 1522757..1604598 | 81841 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11639.59 Da Isoelectric Point: 5.8808
>T135654 WP_167415266.1 NZ_CP042449:c1532731-1532429 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVKRLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVKRLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T135654 NZ_CP042449:c1532731-1532429 [Vibrio alginolyticus]
ATGGCTGAAATAATTTGGACTGAGCCAGCGCTATCCGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTTAAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCAC
CTGAACTAGAACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA
ATGGCTGAAATAATTTGGACTGAGCCAGCGCTATCCGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTTAAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCAC
CTGAACTAGAACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT135654 WP_005448240.1 NZ_CP042449:c1532976-1532719 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT135654 NZ_CP042449:c1532976-1532719 [Vibrio alginolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGCTTGGCGA
TTCTTGAAGGTATTGCGCGAGGTGAACGTGCATTAGCAGACGGTAAAGTGGTAAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGCTTGGCGA
TTCTTGAAGGTATTGCGCGAGGTGAACGTGCATTAGCAGACGGTAAAGTGGTAAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|