Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-vapB/DUF433(antitoxin)
Location 2953639..2954132 Replicon chromosome
Accession NZ_CP042382
Organism Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag FGL86_RS13985 Protein ID WP_147185152.1
Coordinates 2953639..2953899 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FGL86_RS13990 Protein ID WP_147185153.1
Coordinates 2953908..2954132 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL86_RS13940 2948643..2949641 - 999 WP_147185144.1 UDP-N-acetylglucosamine 4,6-dehydratase (inverting) -
FGL86_RS13945 2949721..2949924 + 204 WP_147185145.1 type II toxin-antitoxin system RelE/ParE family toxin -
FGL86_RS13950 2949941..2950249 + 309 WP_147185146.1 HigA family addiction module antidote protein -
FGL86_RS13955 2950378..2950773 - 396 WP_147185147.1 hypothetical protein -
FGL86_RS13960 2950833..2951177 - 345 WP_186764411.1 DUF2335 domain-containing protein -
FGL86_RS17960 2951202..2951357 - 156 WP_186764412.1 hypothetical protein -
FGL86_RS13965 2951347..2951556 - 210 WP_147185149.1 hypothetical protein -
FGL86_RS13970 2951603..2952664 - 1062 WP_147185150.1 transposase -
FGL86_RS13975 2952686..2953102 + 417 WP_147184266.1 IS200/IS605 family transposase -
FGL86_RS13980 2953394..2953633 - 240 WP_147185151.1 DUF2442 domain-containing protein -
FGL86_RS13985 2953639..2953899 - 261 WP_147185152.1 DUF4160 domain-containing protein Toxin
FGL86_RS13990 2953908..2954132 - 225 WP_147185153.1 DUF433 domain-containing protein Antitoxin
FGL86_RS13995 2954233..2956041 - 1809 WP_147185154.1 ABC transporter ATP-binding protein/permease -
FGL86_RS14000 2956175..2957587 - 1413 WP_147185155.1 MBL fold metallo-hydrolase -
FGL86_RS17965 2957599..2958864 - 1266 WP_186764524.1 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2931340..2954132 22792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-70)

Antitoxin

Protein of unknown function DUF433

(7-62)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10225.77 Da        Isoelectric Point: 4.8278

>T135643 WP_147185152.1 NZ_CP042382:c2953899-2953639 [Pistricoccus aurantiacus]
MPTISAFFGILIRMYYDDHNPPHFHAYYGEYEAIITIQTLELMEGKLPRRALAMVVEWAVEHREQLMEDWALAEQHRPLN
KIEPLE

Download         Length: 261 bp

>T135643 NZ_CP042382:c2953899-2953639 [Pistricoccus aurantiacus]
ATGCCAACGATCTCAGCGTTCTTCGGCATCTTGATTCGCATGTATTACGATGATCATAACCCGCCACACTTCCATGCTTA
CTACGGCGAATATGAAGCGATCATCACAATTCAAACTCTGGAACTCATGGAAGGTAAACTGCCGAGGCGTGCACTAGCGA
TGGTGGTGGAGTGGGCCGTTGAGCATCGTGAGCAGCTTATGGAAGATTGGGCTCTAGCAGAGCAACACAGGCCACTTAAC
AAGATCGAGCCTTTGGAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8374.52 Da        Isoelectric Point: 4.3304

>AT135643 WP_147185153.1 NZ_CP042382:c2954132-2953908 [Pistricoccus aurantiacus]
MSELHRITYDPELCGGRPCIRGMRIRVKDILDLLAADATREEILEDFPYLETEDITAALEYAARQSDHPVLSVA

Download         Length: 225 bp

>AT135643 NZ_CP042382:c2954132-2953908 [Pistricoccus aurantiacus]
ATGAGCGAATTGCACCGTATAACATACGATCCTGAATTATGTGGTGGACGCCCTTGTATTCGTGGCATGCGCATTCGTGT
CAAAGACATTTTAGATCTCTTGGCCGCTGATGCTACACGCGAAGAGATACTGGAAGATTTTCCTTATCTTGAAACCGAGG
ATATCACCGCTGCGCTAGAATACGCCGCTCGCCAAAGCGATCATCCTGTACTATCGGTCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References