Detailed information of TA system TA135641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1625080..1625695
• Replicon: chromosome
• Accession: NZ_CP042382
• Organism: Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FGL86_RS07800
• Protein ID: WP_147184041.1
• Coordinates: 1625080..1625262 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FGL86_RS07805
• Protein ID: WP_147184042.1
• Coordinates: 1625291..1625695 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL86_RS07785	1621312..1621722	-	411	WP_147184039.1	MerR family transcriptional regulator	-
FGL86_RS07790	1622089..1623453	+	1365	WP_147184040.1	outer membrane protein transport protein	-
FGL86_RS07795	1623519..1624839	-	1321	Protein_1513	IS4 family transposase	-
FGL86_RS07800	1625080..1625262	+	183	WP_147184041.1	type II toxin-antitoxin system HicA family toxin	Toxin
FGL86_RS07805	1625291..1625695	+	405	WP_147184042.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FGL86_RS07810	1625707..1627305	-	1599	WP_147184043.1	ABC transporter ATP-binding protein	-
FGL86_RS07815	1627315..1628244	-	930	WP_147184044.1	ABC transporter permease subunit	-
FGL86_RS07820	1628250..1629176	-	927	WP_147184045.1	oligopeptide ABC transporter permease OppB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6738.86 Da
• Isoelectric Point: 11.6882

>T135641 WP_147184041.1 NZ_CP042382:1625080-1625262 [Pistricoccus aurantiacus]
VKSRQLIKELEASGWRLDRIAGSHHIFKHPERPGAVPVPHPRKDLPKGTVNSIRKQAGLK

Nucleotide

• Length: 183 bp

>T135641 NZ_CP042382:1625080-1625262 [Pistricoccus aurantiacus]
GTGAAAAGCAGACAGCTCATCAAGGAACTGGAAGCATCAGGATGGCGGCTGGATCGCATCGCGGGTAGTCATCACATATT
CAAACATCCCGAGCGCCCCGGCGCGGTGCCGGTTCCACATCCGAGAAAGGATTTACCAAAGGGCACCGTCAACAGCATAC
GAAAGCAGGCAGGACTCAAGTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14557.50 Da
• Isoelectric Point: 4.5773

>AT135641 WP_147184042.1 NZ_CP042382:1625291-1625695 [Pistricoccus aurantiacus]
MQYPIAIEWGDDKTATGIVFPDIPGAITAGDTVEQAYEAAVEVAHIQLEELAAAGEPIPVPGNIDKHRQNPEFAGWGWGI
IYIDVTPYLGKTEKVNVTLPGIVIRQIDEYVSLHGVKSRSAFLASAALEKLHHQ

Nucleotide

• Length: 405 bp

>AT135641 NZ_CP042382:1625291-1625695 [Pistricoccus aurantiacus]
ATGCAGTATCCCATCGCCATAGAGTGGGGTGACGACAAAACCGCCACCGGCATCGTCTTTCCCGACATTCCCGGCGCGAT
CACCGCCGGCGACACTGTCGAGCAGGCTTACGAAGCTGCCGTCGAAGTGGCGCATATTCAACTCGAGGAGCTGGCTGCCG
CCGGTGAGCCGATTCCCGTTCCGGGGAATATCGACAAACACCGTCAGAACCCTGAGTTTGCTGGCTGGGGCTGGGGCATC
ATCTATATCGACGTCACGCCTTATCTTGGCAAGACGGAAAAGGTCAACGTCACGCTGCCCGGTATCGTTATCCGCCAGAT
CGATGAATACGTGAGCCTGCACGGGGTCAAGAGCCGCTCGGCGTTTCTCGCCAGCGCCGCGCTGGAAAAACTGCACCATC
AGTAA