Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1625080..1625695 Replicon chromosome
Accession NZ_CP042382
Organism Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGL86_RS07800 Protein ID WP_147184041.1
Coordinates 1625080..1625262 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGL86_RS07805 Protein ID WP_147184042.1
Coordinates 1625291..1625695 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL86_RS07785 1621312..1621722 - 411 WP_147184039.1 MerR family transcriptional regulator -
FGL86_RS07790 1622089..1623453 + 1365 WP_147184040.1 outer membrane protein transport protein -
FGL86_RS07795 1623519..1624839 - 1321 Protein_1513 IS4 family transposase -
FGL86_RS07800 1625080..1625262 + 183 WP_147184041.1 type II toxin-antitoxin system HicA family toxin Toxin
FGL86_RS07805 1625291..1625695 + 405 WP_147184042.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGL86_RS07810 1625707..1627305 - 1599 WP_147184043.1 ABC transporter ATP-binding protein -
FGL86_RS07815 1627315..1628244 - 930 WP_147184044.1 ABC transporter permease subunit -
FGL86_RS07820 1628250..1629176 - 927 WP_147184045.1 oligopeptide ABC transporter permease OppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6738.86 Da        Isoelectric Point: 11.6882

>T135641 WP_147184041.1 NZ_CP042382:1625080-1625262 [Pistricoccus aurantiacus]
VKSRQLIKELEASGWRLDRIAGSHHIFKHPERPGAVPVPHPRKDLPKGTVNSIRKQAGLK

Download         Length: 183 bp

>T135641 NZ_CP042382:1625080-1625262 [Pistricoccus aurantiacus]
GTGAAAAGCAGACAGCTCATCAAGGAACTGGAAGCATCAGGATGGCGGCTGGATCGCATCGCGGGTAGTCATCACATATT
CAAACATCCCGAGCGCCCCGGCGCGGTGCCGGTTCCACATCCGAGAAAGGATTTACCAAAGGGCACCGTCAACAGCATAC
GAAAGCAGGCAGGACTCAAGTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14557.50 Da        Isoelectric Point: 4.5773

>AT135641 WP_147184042.1 NZ_CP042382:1625291-1625695 [Pistricoccus aurantiacus]
MQYPIAIEWGDDKTATGIVFPDIPGAITAGDTVEQAYEAAVEVAHIQLEELAAAGEPIPVPGNIDKHRQNPEFAGWGWGI
IYIDVTPYLGKTEKVNVTLPGIVIRQIDEYVSLHGVKSRSAFLASAALEKLHHQ

Download         Length: 405 bp

>AT135641 NZ_CP042382:1625291-1625695 [Pistricoccus aurantiacus]
ATGCAGTATCCCATCGCCATAGAGTGGGGTGACGACAAAACCGCCACCGGCATCGTCTTTCCCGACATTCCCGGCGCGAT
CACCGCCGGCGACACTGTCGAGCAGGCTTACGAAGCTGCCGTCGAAGTGGCGCATATTCAACTCGAGGAGCTGGCTGCCG
CCGGTGAGCCGATTCCCGTTCCGGGGAATATCGACAAACACCGTCAGAACCCTGAGTTTGCTGGCTGGGGCTGGGGCATC
ATCTATATCGACGTCACGCCTTATCTTGGCAAGACGGAAAAGGTCAACGTCACGCTGCCCGGTATCGTTATCCGCCAGAT
CGATGAATACGTGAGCCTGCACGGGGTCAAGAGCCGCTCGGCGTTTCTCGCCAGCGCCGCGCTGGAAAAACTGCACCATC
AGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References