Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 754427..755029 Replicon chromosome
Accession NZ_CP042382
Organism Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGL86_RS03535 Protein ID WP_147183305.1
Coordinates 754427..754621 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGL86_RS03540 Protein ID WP_147183306.1
Coordinates 754631..755029 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL86_RS03520 750434..751906 + 1473 WP_186764514.1 DNA recombination protein RmuC -
FGL86_RS03525 751916..752884 + 969 Protein_687 GlxA family transcriptional regulator -
FGL86_RS03530 752981..754297 + 1317 WP_147183304.1 TauD/TfdA family dioxygenase -
FGL86_RS03535 754427..754621 + 195 WP_147183305.1 type II toxin-antitoxin system HicA family toxin Toxin
FGL86_RS03540 754631..755029 + 399 WP_147183306.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGL86_RS03545 755053..755802 - 750 WP_147186069.1 NAD(P)H-dependent oxidoreductase -
FGL86_RS03550 755852..756733 + 882 WP_147183307.1 LysR family transcriptional regulator -
FGL86_RS03555 756812..757102 + 291 WP_147183308.1 hypothetical protein -
FGL86_RS03560 757194..758201 - 1008 WP_147183309.1 helix-turn-helix domain-containing protein -
FGL86_RS03565 758305..759477 + 1173 WP_147183310.1 TauD/TfdA family dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-123)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7378.51 Da        Isoelectric Point: 11.0643

>T135635 WP_147183305.1 NZ_CP042382:754427-754621 [Pistricoccus aurantiacus]
MKRYSSRELIKMLKADGWEPVAVAGSHDQFKHPDKPGRVTVPHPRKDLPTPTIRSIFRQAGWQQ

Download         Length: 195 bp

>T135635 NZ_CP042382:754427-754621 [Pistricoccus aurantiacus]
ATGAAGCGATACAGCAGTCGAGAACTGATCAAGATGCTCAAGGCTGACGGTTGGGAGCCGGTCGCGGTTGCCGGCTCGCA
CGATCAGTTCAAGCATCCTGACAAACCCGGCCGCGTCACCGTCCCCCATCCCAGGAAAGACCTGCCCACGCCGACGATTC
GCAGTATCTTCCGCCAGGCCGGCTGGCAGCAATAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14405.28 Da        Isoelectric Point: 4.3744

>AT135635 WP_147183306.1 NZ_CP042382:754631-755029 [Pistricoccus aurantiacus]
MAHYIALLHHEDDAYGVVFPDFPGCVSAGDNFEDALRMGAEALAFHVAGMQEDGEAIPAPRSLEQIKATGDDWIEWDNAL
VTLIPLLPPPDISERVNVTLPKRLLVQIDAISRNRSGFLAQAAAEALRQRSS

Download         Length: 399 bp

>AT135635 NZ_CP042382:754631-755029 [Pistricoccus aurantiacus]
ATGGCGCACTATATTGCTTTGCTGCATCATGAAGACGATGCCTATGGCGTCGTCTTTCCCGACTTCCCCGGTTGCGTCAG
CGCCGGCGACAACTTTGAAGATGCTCTTCGCATGGGCGCCGAAGCACTGGCCTTTCATGTGGCCGGCATGCAGGAAGACG
GTGAGGCGATTCCCGCCCCACGTAGCCTGGAGCAGATCAAGGCCACCGGTGACGACTGGATCGAATGGGATAATGCTCTG
GTCACCCTGATACCGCTGCTGCCCCCGCCGGATATCTCCGAGCGCGTCAACGTCACCCTGCCCAAACGGTTGCTGGTCCA
GATCGACGCCATCTCGCGCAATCGCTCCGGCTTTCTCGCCCAGGCGGCCGCCGAGGCGCTGCGCCAGCGGAGTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References