Detailed information of TA system TA135635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 754427..755029
• Replicon: chromosome
• Accession: NZ_CP042382
• Organism: Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FGL86_RS03535
• Protein ID: WP_147183305.1
• Coordinates: 754427..754621 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FGL86_RS03540
• Protein ID: WP_147183306.1
• Coordinates: 754631..755029 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL86_RS03520	750434..751906	+	1473	WP_186764514.1	DNA recombination protein RmuC	-
FGL86_RS03525	751916..752884	+	969	Protein_687	GlxA family transcriptional regulator	-
FGL86_RS03530	752981..754297	+	1317	WP_147183304.1	TauD/TfdA family dioxygenase	-
FGL86_RS03535	754427..754621	+	195	WP_147183305.1	type II toxin-antitoxin system HicA family toxin	Toxin
FGL86_RS03540	754631..755029	+	399	WP_147183306.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FGL86_RS03545	755053..755802	-	750	WP_147186069.1	NAD(P)H-dependent oxidoreductase	-
FGL86_RS03550	755852..756733	+	882	WP_147183307.1	LysR family transcriptional regulator	-
FGL86_RS03555	756812..757102	+	291	WP_147183308.1	hypothetical protein	-
FGL86_RS03560	757194..758201	-	1008	WP_147183309.1	helix-turn-helix domain-containing protein	-
FGL86_RS03565	758305..759477	+	1173	WP_147183310.1	TauD/TfdA family dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-123)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7378.51 Da
• Isoelectric Point: 11.0643

>T135635 WP_147183305.1 NZ_CP042382:754427-754621 [Pistricoccus aurantiacus]
MKRYSSRELIKMLKADGWEPVAVAGSHDQFKHPDKPGRVTVPHPRKDLPTPTIRSIFRQAGWQQ

Nucleotide

• Length: 195 bp

>T135635 NZ_CP042382:754427-754621 [Pistricoccus aurantiacus]
ATGAAGCGATACAGCAGTCGAGAACTGATCAAGATGCTCAAGGCTGACGGTTGGGAGCCGGTCGCGGTTGCCGGCTCGCA
CGATCAGTTCAAGCATCCTGACAAACCCGGCCGCGTCACCGTCCCCCATCCCAGGAAAGACCTGCCCACGCCGACGATTC
GCAGTATCTTCCGCCAGGCCGGCTGGCAGCAATAG

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14405.28 Da
• Isoelectric Point: 4.3744

>AT135635 WP_147183306.1 NZ_CP042382:754631-755029 [Pistricoccus aurantiacus]
MAHYIALLHHEDDAYGVVFPDFPGCVSAGDNFEDALRMGAEALAFHVAGMQEDGEAIPAPRSLEQIKATGDDWIEWDNAL
VTLIPLLPPPDISERVNVTLPKRLLVQIDAISRNRSGFLAQAAAEALRQRSS

Nucleotide

• Length: 399 bp

>AT135635 NZ_CP042382:754631-755029 [Pistricoccus aurantiacus]
ATGGCGCACTATATTGCTTTGCTGCATCATGAAGACGATGCCTATGGCGTCGTCTTTCCCGACTTCCCCGGTTGCGTCAG
CGCCGGCGACAACTTTGAAGATGCTCTTCGCATGGGCGCCGAAGCACTGGCCTTTCATGTGGCCGGCATGCAGGAAGACG
GTGAGGCGATTCCCGCCCCACGTAGCCTGGAGCAGATCAAGGCCACCGGTGACGACTGGATCGAATGGGATAATGCTCTG
GTCACCCTGATACCGCTGCTGCCCCCGCCGGATATCTCCGAGCGCGTCAACGTCACCCTGCCCAAACGGTTGCTGGTCCA
GATCGACGCCATCTCGCGCAATCGCTCCGGCTTTCTCGCCCAGGCGGCCGCCGAGGCGCTGCGCCAGCGGAGTTCGTGA