Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 607460..608093 Replicon chromosome
Accession NZ_CP042382
Organism Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGL86_RS02870 Protein ID WP_147183183.1
Coordinates 607460..607642 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGL86_RS02875 Protein ID WP_147183184.1
Coordinates 607680..608093 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL86_RS02845 602501..603793 + 1293 WP_147186058.1 M20/M25/M40 family metallo-hydrolase -
FGL86_RS02850 603921..604244 + 324 WP_147183179.1 hypothetical protein -
FGL86_RS02855 604402..605649 + 1248 WP_147183180.1 dicarboxylate/amino acid:cation symporter -
FGL86_RS02860 605874..606035 + 162 WP_147183181.1 metallothionein -
FGL86_RS17875 606083..606259 + 177 WP_186764460.1 hypothetical protein -
FGL86_RS02865 606350..607387 + 1038 WP_147183182.1 peptidase C45 acyl-coenzyme A--6- aminopenicillanic acid acyl-transferase -
FGL86_RS02870 607460..607642 + 183 WP_147183183.1 type II toxin-antitoxin system HicA family toxin Toxin
FGL86_RS02875 607680..608093 + 414 WP_147183184.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGL86_RS02880 608101..608685 - 585 WP_147183185.1 DUF4202 domain-containing protein -
FGL86_RS02885 608756..608896 - 141 WP_147183186.1 ribosome alternative rescue factor ArfA -
FGL86_RS02890 609215..611062 - 1848 WP_147183187.1 cadmium-translocating P-type ATPase -
FGL86_RS02895 611157..611393 - 237 WP_147183188.1 heavy-metal-associated domain-containing protein -
FGL86_RS02900 611436..612029 - 594 WP_147183189.1 hypothetical protein -
FGL86_RS02905 612213..613058 - 846 WP_147183190.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6824.97 Da        Isoelectric Point: 11.0703

>T135634 WP_147183183.1 NZ_CP042382:607460-607642 [Pistricoccus aurantiacus]
VKSSDFIKELEANGWRLDRVKGSHHHFRHADMLGTITVPHPKKDLKKGLVQAIRKQAGLK

Download         Length: 183 bp

>T135634 NZ_CP042382:607460-607642 [Pistricoccus aurantiacus]
GTGAAAAGCAGTGATTTTATCAAAGAACTTGAAGCGAATGGATGGCGTCTTGATCGAGTAAAAGGTAGCCATCATCATTT
TAGACACGCGGATATGCTTGGCACTATTACCGTGCCTCATCCAAAAAAAGATCTAAAAAAGGGCTTGGTACAAGCGATTA
GAAAACAAGCTGGACTCAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15177.00 Da        Isoelectric Point: 4.6492

>AT135634 WP_147183184.1 NZ_CP042382:607680-608093 [Pistricoccus aurantiacus]
MHYPIAIEVGDEQHAYSVVVPDLPGCFSAGDTFDDAIANAREAIEGHLESLAEHGDPIPTATTIQQYLKEPEYAGWVWAA
VEIDMTPYLGKSHKINVTLPDLLIKRIDNTVSKQSEYQSRSGFLARAALHELERSAR

Download         Length: 414 bp

>AT135634 NZ_CP042382:607680-608093 [Pistricoccus aurantiacus]
ATGCACTATCCCATTGCCATTGAAGTCGGCGATGAGCAGCACGCCTATAGCGTGGTAGTACCCGATTTGCCGGGGTGTTT
CTCTGCCGGTGATACCTTCGATGACGCAATTGCCAACGCCCGCGAGGCTATCGAGGGTCATCTGGAAAGCCTGGCCGAGC
ATGGCGATCCTATTCCTACCGCAACCACCATTCAGCAATATTTGAAAGAACCCGAGTACGCTGGCTGGGTATGGGCGGCA
GTCGAAATCGACATGACCCCATATCTGGGAAAAAGCCATAAAATAAACGTGACGCTGCCCGATCTATTGATCAAACGCAT
CGACAACACCGTTTCCAAACAGAGCGAGTATCAAAGCCGCTCCGGCTTTTTAGCTCGTGCCGCATTACACGAGCTGGAGC
GCAGCGCACGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References