Detailed information of TA system TA135633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 476200..476858
• Replicon: chromosome
• Accession: NZ_CP042382
• Organism: Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FGL86_RS02190
• Protein ID: WP_147183068.1
• Coordinates: 476200..476598 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FGL86_RS02195
• Protein ID: WP_147183069.1
• Coordinates: 476595..476858 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL86_RS02175	472133..472906	-	774	WP_147183065.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
FGL86_RS02180	473163..474539	+	1377	WP_147183066.1	glutamine synthetase family protein	-
FGL86_RS02185	474582..476123	+	1542	WP_147183067.1	sodium:proton antiporter	-
FGL86_RS02190	476200..476598	-	399	WP_147183068.1	type II toxin-antitoxin system VapC family toxin	Toxin
FGL86_RS02195	476595..476858	-	264	WP_147183069.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FGL86_RS02200	476986..478272	-	1287	WP_186764458.1	FAD-binding oxidoreductase	-
FGL86_RS02205	478451..478942	-	492	WP_147183071.1	hypothetical protein	-
FGL86_RS02210	478941..479822	+	882	WP_147183072.1	carboxylate/amino acid/amine transporter	-
FGL86_RS02215	479904..481205	-	1302	WP_147183073.1	4-aminobutyrate--2-oxoglutarate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-58)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14853.38 Da
• Isoelectric Point: 8.5039

>T135633 WP_147183068.1 NZ_CP042382:c476598-476200 [Pistricoccus aurantiacus]
MKRIMLDTNMVSHFIKGHATVNAHVLAAPMAALCISVVTEAELRYGLAKRPQAKQLKRVVEEFLCRVDVLPWNSPLTRRY
GEVRAKLEQGGKTLGALDLLIAVHALEVDALLVTNDHAFYYVDGLRIEDWTR

Nucleotide

• Length: 399 bp

>T135633 NZ_CP042382:c476598-476200 [Pistricoccus aurantiacus]
ATGAAGCGCATCATGTTGGATACCAACATGGTCAGTCACTTCATCAAGGGGCATGCGACGGTGAATGCGCACGTCCTGGC
GGCTCCGATGGCCGCGCTTTGCATCTCCGTGGTTACGGAAGCGGAGCTGCGCTATGGGCTTGCCAAGCGCCCCCAAGCCA
AGCAGCTGAAAAGAGTCGTGGAGGAATTCCTGTGTCGGGTGGATGTGCTTCCCTGGAATAGCCCGCTGACCCGGCGTTAC
GGAGAGGTGAGAGCGAAGCTTGAGCAAGGCGGGAAAACCCTGGGCGCTCTGGACCTGCTTATCGCCGTGCATGCTTTGGA
AGTCGACGCCTTGCTGGTGACCAACGACCATGCCTTTTACTATGTCGATGGCCTGCGTATCGAAGACTGGACTCGATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10102.23 Da
• Isoelectric Point: 5.1465

>AT135633 WP_147183069.1 NZ_CP042382:c476858-476595 [Pistricoccus aurantiacus]
MGQKARLFQNGRSQAVRLPVAYRFDDCDEVFIRRDPATGDVIISRRPANWDSFLAARQKAAIDQGFLDSEERKQTVQERD
PFAEWNE

Nucleotide

• Length: 264 bp

>AT135633 NZ_CP042382:c476858-476595 [Pistricoccus aurantiacus]
ATGGGTCAGAAAGCTCGTCTTTTCCAGAACGGTCGAAGCCAAGCCGTGCGCTTGCCCGTCGCTTATCGCTTCGATGACTG
TGACGAAGTATTCATTCGGCGTGATCCGGCAACCGGCGACGTGATCATCTCGCGCAGGCCTGCCAACTGGGACTCCTTCC
TGGCGGCACGTCAAAAGGCCGCCATCGACCAGGGGTTTCTTGACTCTGAAGAGCGTAAACAAACCGTCCAGGAGCGCGAC
CCTTTCGCTGAGTGGAACGAATGA