135632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 128331..128914 Replicon chromosome
Accession NZ_CP042382
Organism Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGL86_RS00600 Protein ID WP_147182779.1
Coordinates 128331..128519 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGL86_RS00605 Protein ID WP_147182780.1
Coordinates 128522..128914 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL86_RS00565 123405..123635 + 231 WP_147182776.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FGL86_RS00575 123907..125211 - 1305 WP_147186028.1 IS1380 family transposase -
FGL86_RS00580 125328..125537 + 210 Protein_114 transcriptional modulator of MazE/toxin MazF -
FGL86_RS00585 125630..127015 + 1386 WP_147186029.1 DNA-3-methyladenine glycosylase 2 family protein -
FGL86_RS00590 127017..127481 + 465 WP_147182777.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
FGL86_RS00595 127465..128283 + 819 WP_147182778.1 hypothetical protein -
FGL86_RS00600 128331..128519 + 189 WP_147182779.1 type II toxin-antitoxin system HicA family toxin Toxin
FGL86_RS00605 128522..128914 + 393 WP_147182780.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGL86_RS00610 128985..129560 - 576 WP_147182781.1 Spy/CpxP family protein refolding chaperone -
FGL86_RS00615 129732..130418 + 687 WP_147182782.1 response regulator transcription factor -
FGL86_RS00620 130415..131746 + 1332 WP_147182783.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7069.20 Da        Isoelectric Point: 11.6958

>T135632 WP_147182779.1 NZ_CP042382:128331-128519 [Pistricoccus aurantiacus]
MKSADVIKRLKAEGWQHVGGKGDHMKFKHPARSGHVVVPHPRKDIATGTLRNIYRQAGWAWR

Download         Length: 189 bp

>T135632 NZ_CP042382:128331-128519 [Pistricoccus aurantiacus]
ATGAAAAGCGCAGACGTTATCAAACGGTTGAAAGCCGAAGGCTGGCAACACGTCGGTGGCAAAGGCGATCACATGAAATT
CAAGCATCCGGCGCGATCCGGCCATGTAGTCGTTCCCCATCCTCGCAAAGACATCGCTACCGGAACTCTGCGTAACATCT
ATCGTCAAGCCGGTTGGGCCTGGAGGTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14694.45 Da        Isoelectric Point: 4.0989

>AT135632 WP_147182780.1 NZ_CP042382:128522-128914 [Pistricoccus aurantiacus]
MLYPVYVHKDADSAYGITFPDFPGCFSAADELADLPRMAQEAVEVYFEGENLPIPAPSTPEDWQDDERFQNGYWMLLDID
LSRISTRAVRVNVSLPEWLVARIDEAAGERHLSRSAFLALAAQREMAQTQ

Download         Length: 393 bp

>AT135632 NZ_CP042382:128522-128914 [Pistricoccus aurantiacus]
ATGCTTTACCCCGTTTACGTTCATAAGGATGCCGACAGCGCCTACGGCATTACCTTTCCGGATTTCCCGGGATGCTTTTC
CGCAGCGGACGAACTGGCCGACCTCCCGCGCATGGCGCAAGAAGCCGTCGAAGTATATTTTGAAGGCGAGAATCTACCTA
TTCCTGCACCTTCGACTCCAGAAGACTGGCAGGATGACGAACGCTTTCAGAATGGCTACTGGATGCTGCTCGATATCGAT
CTGTCGAGAATCAGCACCCGTGCGGTACGGGTAAACGTCAGCCTACCGGAATGGCTGGTCGCTCGGATCGACGAAGCCGC
CGGTGAGCGTCATCTCAGCCGCTCGGCTTTTCTGGCTCTGGCCGCGCAGCGTGAAATGGCTCAAACCCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References