135627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 6623..7151 Replicon plasmid pC54_002
Accession NZ_CP042366
Organism Acinetobacter pittii strain C54

Toxin (Protein)


Gene name relE Uniprot ID B0V430
Locus tag FR838_RS20285 Protein ID WP_000221360.1
Coordinates 6858..7151 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0V429
Locus tag FR838_RS20280 Protein ID WP_000246757.1
Coordinates 6623..6868 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR838_RS20245 1926..2147 + 222 Protein_3 IS3 family transposase -
FR838_RS20250 2557..3075 + 519 WP_000447196.1 sel1 repeat family protein -
FR838_RS20255 3207..3719 + 513 WP_001089570.1 SMI1/KNR4 family protein -
FR838_RS20260 3927..4361 + 435 WP_106405795.1 hypothetical protein -
FR838_RS20270 5543..5962 + 420 Protein_8 IS3 family transposase -
FR838_RS20275 6001..6366 + 366 Protein_9 hypothetical protein -
FR838_RS20280 6623..6868 + 246 WP_000246757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FR838_RS20285 6858..7151 + 294 WP_000221360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR838_RS20290 7338..7454 + 117 Protein_12 transposase -
FR838_RS20300 8469..8777 + 309 WP_000269910.1 type II toxin-antitoxin system RelE/ParE family toxin -
FR838_RS20305 8818..9120 + 303 WP_001140619.1 XRE family transcriptional regulator -
FR838_RS20310 9113..9322 + 210 WP_000069470.1 hypothetical protein -
FR838_RS20315 9432..9659 - 228 WP_000555567.1 hypothetical protein -
FR838_RS20325 10425..10728 - 304 Protein_17 helix-turn-helix domain-containing protein -
FR838_RS20330 10721..11077 - 357 WP_000269908.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..76008 76008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11317.49 Da        Isoelectric Point: 10.4753

>T135627 WP_000221360.1 NZ_CP042366:6858-7151 [Acinetobacter pittii]
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T135627 NZ_CP042366:6858-7151 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9264.63 Da        Isoelectric Point: 4.2821

>AT135627 WP_000246757.1 NZ_CP042366:6623-6868 [Acinetobacter pittii]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L

Download         Length: 246 bp

>AT135627 NZ_CP042366:6623-6868 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RR87

Antitoxin

Source ID Structure
AlphaFold DB A0A009MZ79

References