Detailed information of TA system TA135623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3460408..3461087
• Replicon: chromosome
• Accession: NZ_CP042364
• Organism: Acinetobacter pittii strain C54

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FR838_RS16755
• Protein ID: WP_000838146.1
• Coordinates: 3460408..3460590 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A915WMT7
• Locus tag: FR838_RS16760
• Protein ID: WP_023187967.1
• Coordinates: 3460683..3461087 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR838_RS16720	3455632..3456036	+	405	WP_002121581.1	hypothetical protein	-
FR838_RS16725	3456008..3456376	+	369	WP_000539743.1	hypothetical protein	-
FR838_RS16730	3456378..3456776	+	399	WP_002121567.1	hypothetical protein	-
FR838_RS16735	3456845..3457198	+	354	WP_002121621.1	hypothetical protein	-
FR838_RS16740	3457198..3458526	+	1329	WP_023187966.1	hypothetical protein	-
FR838_RS16745	3458579..3459496	+	918	WP_002121543.1	hypothetical protein	-
FR838_RS16750	3459567..3460082	+	516	WP_025464105.1	hypothetical protein	-
FR838_RS16755	3460408..3460590	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FR838_RS16760	3460683..3461087	+	405	WP_023187967.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FR838_RS16765	3461186..3461866	+	681	WP_000721572.1	hypothetical protein	-
FR838_RS16770	3461868..3462131	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3435696..3484982	49286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T135623 WP_000838146.1 NZ_CP042364:3460408-3460590 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T135623 NZ_CP042364:3460408-3460590 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14663.74 Da
• Isoelectric Point: 4.4328

>AT135623 WP_023187967.1 NZ_CP042364:3460683-3461087 [Acinetobacter pittii]
MLYLIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT135623 NZ_CP042364:3460683-3461087 [Acinetobacter pittii]
ATGTTATATCTAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7