Detailed information of TA system TA135622

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1667819..1668472
• Replicon: chromosome
• Accession: NZ_CP042364
• Organism: Acinetobacter pittii strain C54

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FR838_RS07930
• Protein ID: WP_057066725.1
• Coordinates: 1667819..1668208 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A009HHW9
• Locus tag: FR838_RS07935
• Protein ID: WP_002117064.1
• Coordinates: 1668215..1668472 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR838_RS07915	1662910..1665120	-	2211	WP_002116854.1	TRAP transporter large permease subunit	-
FR838_RS07920	1665300..1665875	-	576	WP_005078319.1	rhombosortase	-
FR838_RS07925	1665960..1667048	-	1089	WP_002116869.1	hypothetical protein	-
FR838_RS07930	1667819..1668208	-	390	WP_057066725.1	hypothetical protein	Toxin
FR838_RS07935	1668215..1668472	-	258	WP_002117064.1	succinate dehydrogenase assembly factor 2	Antitoxin
FR838_RS07940	1668661..1669833	+	1173	WP_002116790.1	acyl-CoA dehydrogenase family protein	-
FR838_RS07945	1669884..1671374	-	1491	WP_002116796.1	NAD(P)/FAD-dependent oxidoreductase	-
FR838_RS07950	1671556..1671933	-	378	WP_002049717.1	50S ribosomal protein L17	-
FR838_RS07955	1671952..1672959	-	1008	WP_002116730.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15503.68 Da
• Isoelectric Point: 8.7337

>T135622 WP_057066725.1 NZ_CP042364:c1668208-1667819 [Acinetobacter pittii]
MIKELNFELKYSLVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRAEITKIIDYQLFVVIYLEETPKNIAIVWFDQLPIQQWKRLKVLEKLY

Nucleotide

• Length: 390 bp

>T135622 NZ_CP042364:c1668208-1667819 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTAAGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10295.73 Da
• Isoelectric Point: 4.4809

>AT135622 WP_002117064.1 NZ_CP042364:c1668472-1668215 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT135622 NZ_CP042364:c1668472-1668215 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A009HHW9