Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 5136654..5137225 Replicon chromosome
Accession NZ_CP042363
Organism Serratia plymuthica strain A294

Toxin (Protein)


Gene name relE Uniprot ID S4YNR1
Locus tag FS592_RS23970 Protein ID WP_020439916.1
Coordinates 5136947..5137225 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag FS592_RS23965 Protein ID WP_004951261.1
Coordinates 5136654..5136923 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS592_RS23950 (FS592_24180) 5132868..5134085 - 1218 WP_004951256.1 aspartate aminotransferase family protein -
FS592_RS23955 (FS592_24185) 5134217..5134792 - 576 WP_006328493.1 aminodeoxychorismate synthase component II -
FS592_RS23960 (FS592_24190) 5134898..5136424 - 1527 WP_006328494.1 DUF853 family protein -
FS592_RS23965 (FS592_24195) 5136654..5136923 + 270 WP_004951261.1 hypothetical protein Antitoxin
FS592_RS23970 (FS592_24200) 5136947..5137225 + 279 WP_020439916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FS592_RS23975 (FS592_24205) 5137226..5137951 - 726 WP_004951264.1 two-component system response regulator BtsR -
FS592_RS23980 (FS592_24210) 5137951..5139636 - 1686 WP_006328506.1 sensor histidine kinase -
FS592_RS23985 (FS592_24215) 5139796..5140365 - 570 WP_006328507.1 peptidylprolyl isomerase A -
FS592_RS23990 (FS592_24225) 5140721..5141059 + 339 WP_006328508.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10242.84 Da        Isoelectric Point: 8.5141

>T135621 WP_020439916.1 NZ_CP042363:5136947-5137225 [Serratia plymuthica]
VTLKWTEPAIADRIAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T135621 NZ_CP042363:5136947-5137225 [Serratia plymuthica]
GTGACACTCAAGTGGACGGAACCCGCAATTGCCGATCGTATAGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAACTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGTCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT135621 WP_004951261.1 NZ_CP042363:5136654-5136923 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT135621 NZ_CP042363:5136654-5136923 [Serratia plymuthica]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCCGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGCCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTAAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAACGTAGATCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4YNR1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References