Detailed information of TA system TA135620

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4422980..4423649
• Replicon: chromosome
• Accession: NZ_CP042363
• Organism: Serratia plymuthica strain A294

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: FS592_RS20725
• Protein ID: WP_006327725.1
• Coordinates: 4422980..4423402 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: FS592_RS20730
• Protein ID: WP_004952428.1
• Coordinates: 4423383..4423649 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS592_RS20705 (FS592_20885)	4418865..4419383	+	519	WP_004952413.1	flavodoxin FldB	-
FS592_RS20710 (FS592_20890)	4419421..4420785	-	1365	WP_004952415.1	cell envelope integrity protein CreD	-
FS592_RS20715 (FS592_20895)	4420870..4422288	-	1419	WP_006327719.1	two-component system sensor histidine kinase CreC	-
FS592_RS20720 (FS592_20900)	4422285..4422980	-	696	WP_004952420.1	two-component system response regulator CreB	-
FS592_RS20725 (FS592_20905)	4422980..4423402	-	423	WP_006327725.1	protein YgfX	Toxin
FS592_RS20730 (FS592_20910)	4423383..4423649	-	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
FS592_RS20735 (FS592_20915)	4423974..4424960	+	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
FS592_RS20740 (FS592_20920)	4425014..4425511	-	498	WP_006327727.1	DUF2165 domain-containing protein	-
FS592_RS20745 (FS592_20925)	4425674..4426351	-	678	WP_004952439.1	hemolysin III family protein	-
FS592_RS20750 (FS592_20930)	4426542..4427150	+	609	WP_004952444.1	HD domain-containing protein	-
FS592_RS20755 (FS592_20935)	4427198..4428523	-	1326	WP_020439700.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T135620 WP_006327725.1 NZ_CP042363:c4423402-4422980 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T135620 NZ_CP042363:c4423402-4422980 [Serratia plymuthica]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGCTACTCTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGTTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTATGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT135620 WP_004952428.1 NZ_CP042363:c4423649-4423383 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT135620 NZ_CP042363:c4423649-4423383 [Serratia plymuthica]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGATATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10