Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3148297..3148922 Replicon chromosome
Accession NZ_CP042363
Organism Serratia plymuthica strain A294

Toxin (Protein)


Gene name hicA Uniprot ID S4YKF9
Locus tag FS592_RS14860 Protein ID WP_020439240.1
Coordinates 3148297..3148479 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID S4YHW4
Locus tag FS592_RS14865 Protein ID WP_006326094.1
Coordinates 3148509..3148922 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS592_RS14850 (FS592_14970) 3143811..3144056 - 246 WP_020439238.1 hypothetical protein -
FS592_RS14855 (FS592_14975) 3144159..3148130 + 3972 WP_235195877.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
FS592_RS14860 (FS592_14980) 3148297..3148479 + 183 WP_020439240.1 type II toxin-antitoxin system HicA family toxin Toxin
FS592_RS14865 (FS592_14985) 3148509..3148922 + 414 WP_006326094.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FS592_RS14870 (FS592_14990) 3148955..3149707 - 753 WP_235195878.1 L-cystine ABC transporter ATP-binding protein TcyN -
FS592_RS14875 (FS592_14995) 3149711..3150373 - 663 WP_004945937.1 cystine ABC transporter permease -
FS592_RS14880 (FS592_15000) 3150373..3151173 - 801 WP_006326095.1 cystine ABC transporter substrate-binding protein -
FS592_RS14885 (FS592_15005) 3151287..3152279 - 993 WP_006326096.1 D-cysteine desulfhydrase -
FS592_RS14890 (FS592_15010) 3152405..3152914 - 510 WP_004945946.1 flagella biosynthesis regulatory protein FliZ -
FS592_RS14895 (FS592_15015) 3152971..3153693 - 723 WP_004945948.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6891.13 Da        Isoelectric Point: 11.0382

>T135619 WP_020439240.1 NZ_CP042363:3148297-3148479 [Serratia plymuthica]
VKSAEPIRLLEREGWVLERIKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T135619 NZ_CP042363:3148297-3148479 [Serratia plymuthica]
GTGAAAAGTGCAGAACCGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
CAAACACCCGAGTTCCCGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15156.85 Da        Isoelectric Point: 4.5728

>AT135619 WP_006326094.1 NZ_CP042363:3148509-3148922 [Serratia plymuthica]
MFYPAYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSVVQQHPGYGSRSAFLAAAARNELLKVD

Download         Length: 414 bp

>AT135619 NZ_CP042363:3148509-3148922 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTAGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGGATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCAGTGGTGCAGCAGCATCCCGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAAAGTCGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4YKF9

Antitoxin

Source ID Structure
AlphaFold DB S4YHW4

References