Detailed information of TA system TA135610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1601770..1602323
• Replicon: chromosome
• Accession: NZ_CP042363
• Organism: Serratia plymuthica strain A294

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: S4YH80
• Locus tag: FS592_RS07605
• Protein ID: WP_020438747.1
• Coordinates: 1602009..1602323 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: S4YG56
• Locus tag: FS592_RS07600
• Protein ID: WP_020438746.1
• Coordinates: 1601770..1602006 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS592_RS07585 (FS592_07655)	1598196..1599734	+	1539	WP_064799409.1	glutathione ABC transporter substrate-binding protein GsiB	-
FS592_RS07590 (FS592_07660)	1599787..1600707	+	921	WP_004942334.1	glutathione ABC transporter permease GsiC	-
FS592_RS07595 (FS592_07665)	1600717..1601625	+	909	WP_004942335.1	glutathione ABC transporter permease GsiD	-
FS592_RS07600 (FS592_07670)	1601770..1602006	+	237	WP_020438746.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FS592_RS07605 (FS592_07675)	1602009..1602323	+	315	WP_020438747.1	CcdB family protein	Toxin
FS592_RS07610 (FS592_07680)	1602357..1603202	-	846	WP_235196101.1	S-formylglutathione hydrolase	-
FS592_RS07615 (FS592_07685)	1603217..1604344	-	1128	WP_004942340.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
FS592_RS07620 (FS592_07690)	1604373..1605290	-	918	WP_235196102.1	LysR family transcriptional regulator	-
FS592_RS07625 (FS592_07695)	1605398..1606555	+	1158	WP_235196103.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11685.58 Da
• Isoelectric Point: 5.8036

>T135610 WP_020438747.1 NZ_CP042363:1602009-1602323 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGI

Nucleotide

• Length: 315 bp

>T135610 NZ_CP042363:1602009-1602323 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACAGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGCCGAGTTGTGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACTCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9078.16 Da
• Isoelectric Point: 6.7184

>AT135610 WP_020438746.1 NZ_CP042363:1601770-1602006 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEENREAIDALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT135610 NZ_CP042363:1601770-1602006 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGGTGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTGCTACGCTGAATGCTGCTTTGGATGCAGAACTGCGTCAGCATGAGATGAGAAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGATGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Structures

Toxin

• AlphaFold DB: S4YH80

Antitoxin

• AlphaFold DB: S4YG56