Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 123970..124706 Replicon plasmid unnamed
Accession NZ_CP042362
Organism Lelliottia amnigena strain A167

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FS593_RS22235 Protein ID WP_011906517.1
Coordinates 123970..124452 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag FS593_RS22240 Protein ID WP_011906518.1
Coordinates 124440..124706 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS593_RS22225 (120382) 120382..121779 - 1398 WP_011906515.1 SrfA family protein -
FS593_RS22230 (122050) 122050..123216 - 1167 WP_223297209.1 VWA domain-containing protein -
FS593_RS22235 (123970) 123970..124452 - 483 WP_011906517.1 GNAT family N-acetyltransferase Toxin
FS593_RS22240 (124440) 124440..124706 - 267 WP_011906518.1 DUF1778 domain-containing protein Antitoxin
FS593_RS22245 (124828) 124828..125328 - 501 WP_049759462.1 hypothetical protein -
FS593_RS22250 (125413) 125413..125592 + 180 WP_063925957.1 thioredoxin family protein -
FS593_RS22255 (126275) 126275..126709 + 435 WP_011906519.1 universal stress protein UspF -
FS593_RS22260 (126978) 126978..127136 + 159 WP_223297210.1 YnfU family zinc-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141490 141490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17670.32 Da        Isoelectric Point: 9.1157

>T135608 WP_011906517.1 NZ_CP042362:c124452-123970 [Lelliottia amnigena]
VGRVTAPEPLSSTHQLAEFVSGETVLDDWLKQRGLKNQAFRTTRTFVVCKTDMKQVAGFYSLATGSVNHVDSTGSLRHNM
PDPIPVIILARLAVDVSFRGKGIGADLLQDAVLRCYRVAENIGVRAIMVHAMTEEAKSFYVHHGFTASQTQERTLFLKLP

Download         Length: 483 bp

>T135608 NZ_CP042362:c124452-123970 [Lelliottia amnigena]
GTGGGACGTGTAACAGCACCAGAACCGTTATCCAGTACCCATCAACTGGCTGAGTTCGTCAGCGGGGAGACTGTGCTCGA
TGACTGGCTTAAACAGAGAGGGTTAAAAAATCAGGCATTCAGAACCACCCGTACGTTTGTGGTTTGTAAAACAGACATGA
AACAGGTTGCCGGTTTTTATTCTCTGGCCACCGGCAGTGTTAACCATGTGGATTCTACGGGAAGCCTCAGGCACAATATG
CCCGATCCAATTCCCGTAATTATACTTGCTCGCCTGGCGGTCGATGTTTCATTCCGTGGAAAAGGGATCGGGGCTGATTT
ACTGCAAGATGCAGTTTTACGCTGTTACCGTGTAGCTGAGAACATTGGTGTCCGTGCGATTATGGTTCATGCAATGACTG
AAGAAGCCAAAAGCTTTTATGTCCACCACGGTTTTACTGCATCGCAAACGCAGGAGCGGACGCTGTTTCTTAAGCTTCCA
TAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10099.51 Da        Isoelectric Point: 4.5010

>AT135608 WP_011906518.1 NZ_CP042362:c124706-124440 [Lelliottia amnigena]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAEHVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT135608 NZ_CP042362:c124706-124440 [Lelliottia amnigena]
ATGAAATCCGATGTTCAACTCAATCTTAGAGCCAAGGAATCTCAACGAGCACTCATTGATGCTGCAGCAGAGATTCTTCA
TAAATCACGCACAGACTTCATCCTGGAAATGGCATGCCAGGCTGCGGAGCATGTGATCCTCGATCGTCGCGTATTCAATT
TTAACGATGAGCAGTATGCAGAGTTCATCGATATGCTCGATGCACCCGTTGCAGATGACCCTGCCATTGATAAACTTCTG
GCCAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References