Detailed information of TA system TA135604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4167749..4168335
• Replicon: chromosome
• Accession: NZ_CP042361
• Organism: Lelliottia amnigena strain A167

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FS593_RS19980
• Protein ID: WP_235134228.1
• Coordinates: 4167749..4168117 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: FS593_RS19985
• Protein ID: WP_235134229.1
• Coordinates: 4168114..4168335 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS593_RS19960 (FS593_20110)	4163213..4164283	-	1071	WP_235134227.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
FS593_RS19965 (FS593_20115)	4164285..4165130	-	846	WP_015960814.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
FS593_RS19970 (FS593_20120)	4165127..4166014	-	888	WP_015960815.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
FS593_RS19975 (FS593_20125)	4166267..4167583	-	1317	WP_041689549.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
FS593_RS19980 (FS593_20130)	4167749..4168117	-	369	WP_235134228.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FS593_RS19985 (FS593_20135)	4168114..4168335	-	222	WP_235134229.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FS593_RS19990 (FS593_20140)	4168423..4169136	-	714	WP_133632481.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
FS593_RS19995 (FS593_20145)	4169138..4169905	-	768	WP_235134230.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
FS593_RS20000 (FS593_20150)	4169902..4171179	-	1278	WP_015960819.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
FS593_RS20005 (FS593_20155)	4171176..4172102	-	927	WP_015960820.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
FS593_RS20010 (FS593_20160)	4172164..4173273	-	1110	WP_235134231.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4162467..4179884	17417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (27-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13605.93 Da
• Isoelectric Point: 6.7256

>T135604 WP_235134228.1 NZ_CP042361:c4168117-4167749 [Lelliottia amnigena]
MTLQFISAEEIVLFHDKLLSVTPGVAGMPDPGRAEALLYRVLNKYEYEGITDIWILAAMHLMAISRGHIFNDGNKRTALF
ITLLFLKRNGIFLVANPAYVDMTVEAAAGRLSLEEIAQRLRG

Nucleotide

• Length: 369 bp

>T135604 NZ_CP042361:c4168117-4167749 [Lelliottia amnigena]
ATGACTCTGCAATTTATCTCAGCGGAAGAGATAGTCCTGTTCCACGACAAATTGCTGAGCGTAACGCCCGGCGTAGCGGG
AATGCCGGATCCAGGCCGTGCAGAAGCACTCCTTTACCGTGTGTTGAATAAATACGAGTATGAAGGTATTACCGATATCT
GGATACTTGCTGCGATGCACTTGATGGCTATTTCTCGTGGTCATATCTTCAACGACGGAAATAAGCGTACGGCGTTATTC
ATCACCTTGCTTTTTCTTAAACGTAACGGCATTTTCCTCGTCGCCAATCCGGCATATGTTGACATGACGGTGGAGGCAGC
CGCTGGGCGTTTATCCCTGGAAGAGATCGCCCAACGCCTGCGTGGGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8081.02 Da
• Isoelectric Point: 5.0348

>AT135604 WP_235134229.1 NZ_CP042361:c4168335-4168114 [Lelliottia amnigena]
MRTMNYSEARQNLASALESAATGTPVTITRRGHKPAVIISADDFERYQAAKLDAEFDAIMSVHGDEIRELADR

Nucleotide

• Length: 222 bp

>AT135604 NZ_CP042361:c4168335-4168114 [Lelliottia amnigena]
ATGCGTACAATGAACTATAGCGAAGCACGACAAAATCTTGCTTCAGCGCTGGAATCCGCAGCTACAGGTACCCCTGTGAC
TATAACGCGCCGAGGGCACAAGCCCGCCGTTATCATCAGCGCGGATGATTTTGAACGTTACCAGGCGGCAAAACTGGATG
CAGAATTTGACGCCATTATGAGCGTCCACGGAGATGAAATAAGGGAATTGGCCGATAGATGA