Detailed information of TA system TA135590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 479548..480064
• Replicon: chromosome
• Accession: NZ_CP042361
• Organism: Lelliottia amnigena strain A167

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FS593_RS02245
• Protein ID: WP_012015848.1
• Coordinates: 479780..480064 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FS593_RS02240
• Protein ID: WP_012015847.1
• Coordinates: 479548..479790 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS593_RS02225 (FS593_02250)	475377..476117	+	741	WP_235134630.1	KDGP aldolase family protein	-
FS593_RS02230 (FS593_02255)	476395..477540	+	1146	WP_235134631.1	lactonase family protein	-
FS593_RS02235 (FS593_02260)	477560..479470	+	1911	WP_235134632.1	PRD domain-containing protein	-
FS593_RS02240 (FS593_02265)	479548..479790	+	243	WP_012015847.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FS593_RS02245 (FS593_02270)	479780..480064	+	285	WP_012015848.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FS593_RS02250 (FS593_02275)	480066..480530	-	465	WP_235134633.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
FS593_RS02255 (FS593_02280)	480690..482828	-	2139	WP_235134634.1	anaerobic ribonucleoside-triphosphate reductase	-
FS593_RS02260 (FS593_02285)	483204..484859	-	1656	WP_235134635.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11018.04 Da
• Isoelectric Point: 10.3778

>T135590 WP_012015848.1 NZ_CP042361:479780-480064 [Lelliottia amnigena]
MTYELAFDPRALKEWYKLGDTVRAQFKKKLAQVLAEPRIKSARLTDLPDCYKIKLRASGYRLVYQVRDDVVMVFVIAVGK
REKLVVYHDANKRL

Nucleotide

• Length: 285 bp

>T135590 NZ_CP042361:479780-480064 [Lelliottia amnigena]
ATGACTTATGAACTCGCGTTCGATCCGCGTGCGCTTAAAGAGTGGTACAAGCTGGGCGATACGGTAAGAGCTCAGTTTAA
GAAGAAACTAGCGCAAGTGCTGGCGGAACCCCGGATTAAATCTGCCCGTTTAACGGATTTGCCTGACTGCTACAAAATCA
AGCTAAGAGCATCTGGCTATCGTCTGGTTTACCAGGTGCGTGATGACGTGGTGATGGTCTTCGTCATAGCGGTAGGGAAA
CGCGAGAAATTAGTCGTTTATCATGACGCCAATAAACGACTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8988.28 Da
• Isoelectric Point: 4.5203

>AT135590 WP_012015847.1 NZ_CP042361:479548-479790 [Lelliottia amnigena]
MATLNVRLDDKLKNEAYAVLEKLNLTPTEAVRLLFQYVAETGRMPVKTVTISDSEEALIQTVRERLNSPQNGIQVSLDDL

Nucleotide

• Length: 243 bp

>AT135590 NZ_CP042361:479548-479790 [Lelliottia amnigena]
ATGGCAACGCTGAACGTCCGTCTGGACGATAAACTTAAAAATGAGGCTTACGCGGTGCTGGAAAAACTTAACCTTACCCC
GACAGAAGCGGTGCGCCTGCTATTCCAGTATGTGGCAGAAACCGGACGTATGCCGGTGAAGACGGTCACGATTAGCGATA
GCGAAGAAGCCCTAATCCAAACCGTCCGCGAGCGGCTAAATAGCCCGCAAAATGGTATCCAGGTTAGTTTGGATGACTTA
TGA