Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 370145..371695 Replicon plasmid unnamed1
Accession NZ_CP042358
Organism Rahnella aquatilis strain H145

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FS594_RS25170 Protein ID WP_235174372.1
Coordinates 370145..371440 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FS594_RS25175 Protein ID WP_235174628.1
Coordinates 371444..371695 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS594_RS25150 (FS594_25320) 365580..367673 + 2094 WP_235174368.1 lipase family protein -
FS594_RS25155 (FS594_25325) 367657..368427 + 771 WP_235174369.1 hypothetical protein -
FS594_RS25160 368438..369235 + 798 WP_235174370.1 hypothetical protein -
FS594_RS25165 369273..370043 + 771 WP_235174371.1 hypothetical protein -
FS594_RS25170 (FS594_25340) 370145..371440 - 1296 WP_235174372.1 type II toxin-antitoxin system HipA family toxin Toxin
FS594_RS25175 (FS594_25345) 371444..371695 - 252 WP_235174628.1 helix-turn-helix domain-containing protein Antitoxin
FS594_RS25180 (FS594_25350) 371947..372657 + 711 WP_129953386.1 GntR family transcriptional regulator -
FS594_RS25185 (FS594_25355) 372663..373862 - 1200 WP_217157958.1 enolase C-terminal domain-like protein -
FS594_RS25190 (FS594_25360) 374185..375585 + 1401 WP_129991098.1 PTS transporter subunit EIIC -
FS594_RS25195 (FS594_25365) 375592..376464 - 873 WP_129953383.1 fumarylacetoacetate hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaRAHN-2 gtrB / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH 1..536322 536322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-398)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 48386.64 Da        Isoelectric Point: 7.2239

>T135585 WP_235174372.1 NZ_CP042358:c371440-370145 [Rahnella aquatilis]
MDKLTLALNGITVGTLEKGGSGEMSFIYHQSWLTRPGARAISLSLPLQADKFRGAVVYNFFDNLLPDNEQIRSRIQARFQ
IPTKQPFDLLSRIGGDCVGAIQLYPEGAQVTPVTEIHAQPLGEKDIEQLLQGYKDAPLGMEADNEDFRISLAGAQEKTAL
LWYRDQWHRPQGSTPTSHILKLPIGYIANNGIDLSESVENEWLCLKIAEQFGFPVAQCDIACFGTQKVLVVERFDRRWSK
DGSWLMRLPQEDFCQALGVAPALKYEADGGPGIARSMKLLLGSQRAGGDRDMFFKSQILFWMLAAIDGHAKNFSVYIEPG
SAYRMTPFYDVMSAFPLMHPTGIPVKKAKMAMAVLGNNRHFHWDRILPRHFVSTAQRVSYSRENVSNMMMEMKDKTEQVI
TEVESMLPADFPAKISHAIFEGLRRQAARLP

Download         Length: 1296 bp

>T135585 NZ_CP042358:c371440-370145 [Rahnella aquatilis]
ATGGATAAGTTAACGCTCGCATTAAATGGCATTACTGTCGGTACGCTGGAAAAAGGCGGCAGTGGTGAAATGTCATTTAT
TTATCATCAAAGCTGGCTCACTCGCCCCGGAGCCCGTGCCATCTCGTTATCATTACCTCTTCAGGCAGATAAATTCCGTG
GCGCGGTGGTATACAACTTTTTCGACAATCTTCTGCCCGATAACGAACAAATACGCAGCCGTATTCAGGCGCGTTTCCAG
ATCCCGACTAAACAACCTTTCGATTTGCTGTCGCGAATAGGCGGTGATTGCGTCGGTGCGATCCAGCTCTATCCTGAAGG
TGCTCAGGTTACGCCTGTCACTGAAATTCATGCCCAACCGCTTGGCGAAAAGGATATCGAGCAGCTTTTGCAGGGATATA
AGGATGCGCCCTTGGGCATGGAGGCTGACAATGAAGATTTTCGCATTTCTCTGGCCGGTGCGCAGGAAAAAACGGCACTG
CTCTGGTATCGCGACCAGTGGCATCGCCCGCAGGGAAGTACGCCCACCAGCCATATTCTTAAACTCCCCATCGGTTACAT
TGCCAACAATGGCATCGATTTAAGTGAGAGTGTGGAGAATGAATGGCTGTGTCTGAAAATAGCGGAGCAATTCGGATTTC
CGGTCGCACAGTGCGACATTGCCTGCTTCGGTACGCAAAAAGTCCTGGTTGTCGAACGTTTCGATCGTCGCTGGTCGAAG
GATGGCTCCTGGCTGATGAGGCTGCCACAGGAGGATTTTTGTCAGGCGTTAGGCGTCGCCCCGGCATTGAAATATGAGGC
TGACGGCGGCCCCGGGATTGCGCGCTCAATGAAGCTCTTGTTAGGTTCTCAACGCGCAGGAGGGGATCGGGACATGTTTT
TTAAGAGCCAGATCCTCTTCTGGATGCTGGCTGCTATCGACGGTCATGCTAAGAATTTCAGTGTTTATATCGAGCCGGGT
AGCGCATACCGTATGACACCGTTTTATGACGTGATGTCAGCATTTCCTCTGATGCATCCAACAGGTATTCCGGTGAAGAA
AGCCAAAATGGCGATGGCGGTACTCGGCAATAACCGGCATTTTCACTGGGACAGGATCCTGCCCCGTCATTTTGTCTCAA
CGGCGCAACGGGTCAGTTACTCGCGAGAAAACGTGTCGAATATGATGATGGAAATGAAGGATAAAACTGAACAAGTGATT
ACAGAAGTGGAATCCATGTTGCCCGCTGATTTTCCAGCAAAAATCAGTCATGCAATTTTTGAAGGCCTTCGGCGTCAGGC
TGCGCGATTGCCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9626.98 Da        Isoelectric Point: 8.5779

>AT135585 WP_235174628.1 NZ_CP042358:c371695-371444 [Rahnella aquatilis]
MNITSTKMLANALRNERKKRKLSQSKMAETIGLKQSTVSEFENYPDGTRLETLFKLLAALDLELQITPRDINPQEKSSWD
QEW

Download         Length: 252 bp

>AT135585 NZ_CP042358:c371695-371444 [Rahnella aquatilis]
ATGAACATTACCTCAACAAAAATGCTGGCAAATGCACTGCGTAATGAGCGTAAAAAGCGCAAACTCAGCCAGAGTAAAAT
GGCTGAGACAATCGGCCTGAAGCAGTCAACGGTTTCAGAGTTTGAAAATTATCCGGATGGTACCCGTCTGGAGACTCTGT
TCAAGTTATTGGCGGCGCTGGATTTAGAGCTACAGATCACGCCAAGGGATATCAATCCCCAGGAAAAGAGTTCCTGGGAT
CAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References