Detailed information of TA system TA135570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 26363..26885
• Replicon: chromosome
• Accession: NZ_CP042357
• Organism: Rahnella aquatilis strain H145

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FS594_RS00120
• Protein ID: WP_129954049.1
• Coordinates: 26601..26885 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8NLY8
• Locus tag: FS594_RS00115
• Protein ID: WP_013573376.1
• Coordinates: 26363..26611 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS594_RS00095 (FS594_00095)	22193..22855	-	663	WP_129991541.1	OmpA family lipoprotein	-
FS594_RS00100 (FS594_00100)	23077..23520	-	444	WP_129954054.1	N-acetyltransferase	-
FS594_RS00105 (FS594_00105)	23517..24089	-	573	WP_217158905.1	DNA-3-methyladenine glycosylase I	-
FS594_RS00110 (FS594_00110)	24281..26287	+	2007	WP_235173492.1	autotransporter domain-containing protein	-
FS594_RS00115 (FS594_00115)	26363..26611	+	249	WP_013573376.1	plasmid stabilization protein	Antitoxin
FS594_RS00120 (FS594_00120)	26601..26885	+	285	WP_129954049.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FS594_RS00125 (FS594_00125)	27131..28045	+	915	WP_014333298.1	glycine--tRNA ligase subunit alpha	-
FS594_RS00130 (FS594_00130)	28055..30124	+	2070	WP_235173493.1	glycine--tRNA ligase subunit beta	-
FS594_RS00135 (FS594_00135)	30190..31479	-	1290	WP_235173494.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.86 Da
• Isoelectric Point: 10.5358

>T135570 WP_129954049.1 NZ_CP042357:26601-26885 [Rahnella aquatilis]
MTYKLNFFKSALKEWKALAPTIKEQFKKKLAERLENPHVASARLCGPKNNRYKIKLKSLGYRLVYQVEEQEIVVTVVAVG
KREGNEAYKLAEKR

Nucleotide

• Length: 285 bp

>T135570 NZ_CP042357:26601-26885 [Rahnella aquatilis]
ATGACCTATAAACTCAACTTTTTCAAATCAGCTTTAAAAGAATGGAAAGCACTTGCCCCAACGATCAAGGAACAATTTAA
AAAGAAACTGGCTGAGCGGCTGGAGAATCCCCACGTGGCTTCTGCCCGCTTATGCGGCCCTAAAAACAACCGCTATAAAA
TCAAATTAAAGAGTCTTGGTTACCGGCTGGTTTATCAGGTAGAGGAGCAGGAAATCGTGGTGACCGTTGTCGCCGTGGGT
AAACGCGAAGGCAACGAAGCGTACAAACTGGCTGAGAAGCGGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9155.35 Da
• Isoelectric Point: 3.9951

>AT135570 WP_013573376.1 NZ_CP042357:26363-26611 [Rahnella aquatilis]
MPFEILTSSAASITELKRDPMGTFSAGEGEAVAILNRNEPAFYCVPPDVYAYFLSLAEDVELNRIMDARQGEERIRLTLD
DL

Nucleotide

• Length: 249 bp

>AT135570 NZ_CP042357:26363-26611 [Rahnella aquatilis]
ATGCCATTTGAAATACTCACTTCCTCAGCTGCAAGTATCACTGAGCTAAAACGTGACCCGATGGGAACGTTTAGCGCAGG
TGAGGGCGAAGCGGTGGCCATCCTTAACCGTAACGAGCCCGCTTTTTATTGTGTTCCACCCGATGTTTACGCCTATTTTC
TGAGTCTTGCAGAAGACGTCGAATTGAACCGCATAATGGATGCGCGGCAGGGTGAAGAAAGGATAAGGCTGACACTGGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: H8NLY8